“…Different approaches have been taken to consider RF variability, one of them being the assessment of uncertainty over the RF and the subsequent CADx model. Mendel et al 5 conducted a study to quantify feature robustness across different mammography unit manufacturers, and Castillo-Lopez et al 6 investigated the potential of uncertainty analysis to improve the evaluation of texture and the appraisal of prediction models from CEDM single-energy images. Yet, possible solutions to consider uncertainty effects have not been fully explored.…”