“…The latter limitation has been addressed in the context of the maximum-likelihood strategy [11,12], and more recently with the quantum Ziv-Zakai and Weiss-Weinstein bounds [13,14], which also incorporate the effect of the prior information. Nevertheless, the previous restrictions are somestimes not taken into account, in spite of the fact that a naive use of the Fisher information can predict schemes with an apparent infinite precision [15][16][17] which are inefficient in practice [4,13,16,18,19]. Since in general it is not possible to foresee when and how the Cramér-Rao bound is going to fail in a concrete practical scenario from the asymptotic theory itself, a closer analysis of those schemes that are asymptotically optimal is needed.…”