“…For MER, the determined value of 52% f %T >MIC was also in good agreement with the clinical breakpoint for microbiological response of 54% determined in patients with lower respiratory tract infections, in which S. aureus was the second‐most abundant pathogen 39. For VAN, the f AUC/MIC breakpoints from the clinical studies40, 41 tended to be fairly higher (125–400) than the calculated values (59–94) of the present work, which could originate from the partly impaired tissue distribution of VAN,42 whereas for MER and LZD, unbound plasma concentrations might be a fair predictor of tissue concentrations,43, 44, 45 if determined under appropriate analytic conditions 24, 46, 47. Yet, the overall “correct” prediction of the PK‐PD index indicates that the developed semimechanistic PK‐PD model might adequately reflect the clinical situation for the antibiotics LZD, MER, and VAN and, hence, might support the validity of the drawn conclusions from the present translational study.…”