Unbalanced translocation of chromosome 3p in Wilms' tumor

Walton, Jill M.; Lee, C.L.Y.; Mikhail, E.L.; Welch, John P.; Gillis, Dianne

doi:10.1016/0022-3468(92)90283-d

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Those authors documented a trisomy 3p (pter → p11) in Wilms' tumor, resulting from unbalanced translocations between chromosomes 3 and 7, as well as chromosomes 3 and 13. The results in our study support the initial findings of Walton et al (1992) with respect to a more localized region of a gain on chromosome 3p. Other disorders have been shown to involve the short arm of chromosome 3, such as small cell lung cancer (chromosome region 3p22→ p21) (Daly et al, 1993) and renal cell carcinoma (Mannens et al, 1990).…”

Section: Identification Of Novel Chromosomal Regions By Cgh Analysis supporting

confidence: 82%

“…The genetic aberration observed in chromosome 3p and 3q therefore suggests a secondary event with respect to Wilms' tumor development in patient E64t. An unbalanced translocation of chromosome 3p in Wilms' tumor was identified by Walton et al (1992). Those authors documented a trisomy 3p (pter → p11) in Wilms' tumor, resulting from unbalanced translocations between chromosomes 3 and 7, as well as chromosomes 3 and 13.…”

Section: Identification Of Novel Chromosomal Regions By Cgh Analysis mentioning

confidence: 99%

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Comparative genomic hybridization and its application to Wilms’ tumorigenesis

Getman¹,

Houseal

Miller

et al. 1998

Cytogenet Genome Res

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Eighty sporadic Wilms’ tumor samples were analyzed by comparative genomic hybridization (CGH) to identify chromosomal regions involved in the etiology of the disease. Twenty percent of the samples showed chromosomal gains or losses. The majority of chromosomal gains and losses were similar to those identified through molecular and cytogenetic studies. Gains were observed on chromosomes 1q, 7q, 8, and 12, whereas losses were found on chromosomes 1p, 4p, 4q, 7p, 16q, 18q, 21q, and 22q. Other genetic aberrations identified in this study included deletions of chromosomes 5p and 15q, as well as gains of discrete loci on chromosomes 3p and 3q. These latter regions have not been previously implicated in Wilms’ tumorigenesis and may contain novel genes relevant to the development and/or progression of this disease.

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Section: Identification Of Novel Chromosomal Regions By Cgh Analysis supporting

confidence: 82%

Section: Identification Of Novel Chromosomal Regions By Cgh Analysis mentioning

confidence: 99%

Comparative genomic hybridization and its application to Wilms’ tumorigenesis

Getman¹,

Houseal

Miller

et al. 1998

Cytogenet Genome Res

View full text Add to dashboard Cite

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“…Genetic studies of WT typically have shown a deletion of the chromosomal region 11p13, which is also the region involved in aniridia and Beckwith‐Wiedmann syndrome. WT also is found in patients with del(11)(p13) but without aniridia or Beckwith‐Wiedmann syndrome [Kaneko et al, 1981, 1983; Walton et al, 1992].…”

Section: Clinical Cytogenetic and Molecular Characteristics Of Renal mentioning

confidence: 99%

Renal cancer: Cytogenetic and molecular genetic aspects

Meloni‐Ehrig

2002

Am. J. Med. Genet.

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To date, much progress has been made in the fields of cytogenetics and molecular genetics of renal tumors. The previous and recent findings have delineated the characteristics of the various tumors, particularly the cytogenetic and molecular differences that exist between papillary and nonpapillary clear cell renal cell carcinomas (RCCs). At the same time, new cytogenetic subtypes have emerged [e.g., t(X;1)] in subtypes of RCC, while in others (e.g., Wilms tumors) several new cytogenetic abnormalities and consequent molecular involvement have been found. In addition to Wilms tumor, papillary RCC, and clear-cell RCC, cytogenetic and fluorescence in situ hybridization analyses have been performed on several other tumors of the kidney, including chromophobic carcinoma, metanephric adenoma, collecting duct carcinoma, transitional cell carcinoma, congenital mesoblastic nephroma, and malignant rhabdoid tumors of the kidney. This review is therefore intended to present a concise update on the cytogenetic and molecular data on renal tumors, focusing mainly on the clinical usefulness of the findings reported in the literature.

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Unbalanced translocation of chromosome 3p in Wilms' tumor

Cited by 2 publications

References 17 publications

Comparative genomic hybridization and its application to Wilms’ tumorigenesis

Comparative genomic hybridization and its application to Wilms’ tumorigenesis

Renal cancer: Cytogenetic and molecular genetic aspects

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