Unanticipated stabilization of zinc-silicate glasses by addition of lanthanum: Implications for therapeutic inorganic ion delivery systems

Kilcup, Nancy; Werner‐Zwanziger, Ulrike; Tonkopi, Elena; Boyd, Daniel

doi:10.1016/j.jnoncrysol.2015.08.028

Cited by 5 publications

(2 citation statements)

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“…The release of ionic compounds in the medium can enhance the pH level of the medium and environment osmotic pressure. These factors are effective in the antibacterial activity of BGs . The chemical composition of BGs and the dissolution condition of their environments effect the antibacterial influence of them …”

Section: Discussionmentioning

confidence: 99%

“…The incorporation of elemental additives such as alkali, alkaline earth, transition and posttransition metals enhances BGs performance and introduces osteoconductivity, angiogenicity and antibacterial properties . Magnesium (Mg) is the fourth most abundant metal cation in the human body and the second most common intracellular cation and approximately 50%–60% of Mg total content is stored in the skeleton .…”

Section: Introductionmentioning

confidence: 99%

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Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

Moghanian

Ghorbanoghli

Kazem‐Rostami

et al. 2019

Int J of Appl Glass Sci

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In this study, six sol‐gel copper/magnesium substituted derivatives of 58S‐BG, that is, a mol% series of 60SiO2–4P2O5–5CuO–(31–x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast‐like cell responses, and bioactive glasses antibacterial performance were studied. X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu‐substituted 58S‐BG consisting of 5 mol% MgO (BG‐5/5) had capability of the formation of HA on its surface while, Cu‐substituted 58S‐BGs consisting 8 mol% and 10 mol% MgO (BG‐5/8 and BG‐5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3‐E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg‐substituted 58S‐BGs displayed antibacterial effect against methicillin‐resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG‐5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.

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Section: Discussionmentioning

confidence: 99%