Unacknowledged adverse transfusion reactions: Are they a mine to dig?

Clinical Usefulness of Furosemide to Prevent Volume Overload Among Children and Young Adults with Transfusion-Dependent Thalassemia: A Randomized, Open-Label, Crossover Study

“…28,29 The role of furosemide in preventing or treating hypertension secondary to red blood cell transfusion among patients with TDT was explored in several studies; however, the results remain controversial [7][8][9]30 and its use varies among institutions. [31][32][33] In addition, several side effects of furosemide have been reported in the literature including hypotension, hyperuricemia, hypokalemia, nephrotoxicity and ototoxicity which make the determination of the real clinical benefits of this drug truly necessary. 24,[34][35][36] N-terminal prohormone of brain natriuretic peptide (NT-proBNP or BNPT) is a biomarker in the blood used to screen, diagnose, and monitor heart failure.…”