Un caso de queratitis micótica por Fusarium solani en Valdivia, Chile

Mena, R G Rodriguez; Carrasco, Eduardo; Godoy-Martínez, Patricio; Stchigel, Alberto M.; Cano-Lira, José F.; Zaror, Luis

doi:10.1016/j.riam.2013.12.001

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…When these pathogens are predominant in an area, they can inflict considerable yield loss on maize production [8,30,31]. In addition, this crop disease can disperse toxins through infected gains, which is a potential health risk for humans and animals [13][14][15]. One of the most effective ways to diminish this problem is through developing highly tolerant or resistant maize plants.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, Fusarium can provoke rots that affect maize yield and grain quality by producing fumonisin or deoxynivalenol (also known as vomitoxin or DON) mycotoxins [7][8][9]. The amount of toxins found in grains used for food production or feeding must; therefore, be taken into consideration, since they are harmful to both animal [10,11] and human health [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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A Global Screening Assay to Select for Maize Phenotypes with a High Tolerance or Resistance to Fusarium verticillioides (Sacc.) Nirenberg Rots

et al. 2020

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Fusarium verticillioides (Sacc.) Nirenberg (Fv) causes rots in maize around the world and produces mycotoxins that contaminate grains, making this species a significant health concern for both animals and humans. One of the best approaches to address rots is to identify highly tolerant or resistant genotypes that can be used for genetic improvement. The aim of the study was to evaluate dose-response assays to tolerance or resistance for Fv rots throughout the maize life cycle. These tests assessed the effects of Fv during post-germination development and the seedling (V2) stage by seed infection, the plantlet (V4) stage by substrate infection, and in the reproductive phase in maize stalks (R2 stage) and ears (R6 stage) by R1 stage inoculation. In all assays, the doses were effective at distinguishing contrasting phenotypes. Severity, root fresh weight, and aerial length were the most informative parameters at the V2 and V4 stages. Evaluation of the stalk necrosis area between and within the internodes of susceptible genotypes revealed significant differences among doses, and a positive correlation between necrosis and conidia concentration was observed in internodes. Injecting eight million conidia in the ear was sufficient for selecting different phenotypes. A total of 85% of the genotypes conserved their same capacity to respond to Fv infection throughout the maize life cycle, so that screening at the early vegetative stage (e.g., V2) could be useful for distinguishing contrasting phenotypes in the reproductive stage. Implementing these screening assays in a maize breeding program could be valuable for classifying the degrees of resilience of maize germplasms to Fv rots. This global screening has the potential to be employed to select against other Fusarium species.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Global Screening Assay to Select for Maize Phenotypes with a High Tolerance or Resistance to Fusarium verticillioides (Sacc.) Nirenberg Rots

et al. 2020

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“…There is only one such report from Chile; however, corneal opacity persisted after treatment in that case. 17 Sequence of both successful and failure treatments with several antifungal approaches, as well with excellent photographs, has also been published, but without using intravenous voriconazole. 18…”

Section: Discussionmentioning

confidence: 99%

Severe mycotic keratoconjunctivitis caused by Fusarium sp. in an immunocompetent child successfully treated with intravenous voriconazole and keratoplasty: case report and short review of the literature

Chacón-Cruz

Male-Valle

Rivas-Landeros

et al. 2018

Therapeutic Advances in Infection

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Background:Pediatric mycotic infections in the eye are uncommon. However, ophthalmic infections by several fungal species have been described in immunocompetent subjects. Mycotic keratitis with or without conjunctivitis (MK) may account for more than 50% of all cases, particularly in tropical and sub-tropical areas. The leading mechanism is trauma. Treatment of MK is managed by medical (antifungal agents) and/or surgical means. This is the first case report of a patient with MK by Fusarium spp. successfully treated with keratoplasty and intravenous voriconazole, along with topical natamycin.Methods:Keratoplasty was performed and cultures obtained. Both Blood and Sabouraud Agars were used for cultures, and Lactophenol Cotton Blue Staining for microscopic observation.Results:A healthy, 10 year-old female, from the sub-tropical area of Sinaloa, Mexico, was admitted at both the CODET Vision Institute and the General Hospital of Tijuana, Mexico. Seven days after a direct trauma of the right cornea, the patient complained of progressive blurred vision, burning sensation, and itchiness. Clinical examination showed severe keratoconjunctivitis, and a necrotic slough on the cornea. Fungal colonies grew, and microscopic visualization showed typical ovoid, sickle-cell shaped macroconidia characteristics of Fusarium spp. The patient received intravenous voriconazole (200 mg every 12 h) and topical natamycin for 7 days prior and 6 days after keratoplasty. Topical natamycin was continued for 3 weeks. At 1-month follow-up, the patient’s outcome was significantly improved, with 90% vision recovery.Conclusion:This is the first pediatric case report of severe MK by Fusarium spp. successfully treated with combined intravenous voriconazole, keratoplasty and topical natamycin.

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“…En general, Fusarium y Aspergillus son los agentes etiológicos más comunmente aislados de pacientes con queratitis micótica en los trópicos, mientras que Cándida albicans en regiones templadas (17) (18) . Diferentes autores establecen que la queratitis por Fusarium es una de las infecciones más comunes de la córnea (19) . En el estudio epidemiológico llevado a cabo por László Kredics y colaboradores se puede apreciar la variación que estos aislamientos han tenido a lo largo de los años y en diferentes países, y se puede observar la tendencia de reportes donde este género predomina como el primer agente causal en diferentes países, seguido de Aspergillus (1) .…”

Section: Discusionesunclassified

Incidencia de queratitis fúngicas en el Hospital Nacional de Clínicas, Córdoba

Burghini

Fraenza

2020

Rev Fac Cien Med Univ Nac Cordoba

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Resumen Introducción: La queratitis fúngica es una infección corneal supurativa grave, generalmente ulcerosa, que puede provocar ceguera o visión reducida. Objetivos: Reportar la incidencia y los agentes causales más comunes de queratitis micóticas en el Hospital Nacional de Clínicas, de la ciudad de Córdoba. Materiales y Métodos: Se llevó a cabo un estudio retrospectivo, descriptivo y comparativo de los registros de casos con diagnóstico de queratitis fúngica en el Hospital Nacional de Clínicas en el período comprendido desde marzo del 2007 a diciembre de 2017 inclusive, analizando las variables edad, sexo y factores predisponentes. Se determinaron porcentajes y frecuencias de los microorganismos recuperados y llevando a cabo un análisis estadístico mediante una prueba de dependencia, determinamos la relación entre sexo de los pacientes e incidencia de queratitis fúngica. Resultados: De los 66 casos positivos respecto de 469 muestras totales, el 57.5% correspondió a Fusarium sp, seguido de Aspergillus sp. La principal causa de queratitis fúngica fue traumatismo con restos de vegetales. Se determinó un promedio de 6 casos diagnosticados por año. Conclusiones: El género predominante fue Fusarium sp, con una incidencia del 14,1% para esta infección en una proporción de 2.9:1 hombres respecto de mujeres.

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Un caso de queratitis micótica por Fusarium solani en Valdivia, Chile

Cited by 3 publications

References 31 publications

A Global Screening Assay to Select for Maize Phenotypes with a High Tolerance or Resistance to Fusarium verticillioides (Sacc.) Nirenberg Rots

A Global Screening Assay to Select for Maize Phenotypes with a High Tolerance or Resistance to Fusarium verticillioides (Sacc.) Nirenberg Rots

Severe mycotic keratoconjunctivitis caused by Fusarium sp. in an immunocompetent child successfully treated with intravenous voriconazole and keratoplasty: case report and short review of the literature

Incidencia de queratitis fúngicas en el Hospital Nacional de Clínicas, Córdoba

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