Un cas d’adénocarcinome colique « trèfle à quatre feuilles »

Paneth cell adenocarcinoma of the colon: A rare entity

“…Histologically, The WHO classification does not define the percentage needed to evoke this diagnosis [12]. The review of the case-rich case histories of Paneth reveals that it is isolated or in 8/25 cases associated with other morphological contingent (colloid and signet ring cells), which is concordant with our case, since we have a predominant well-differentiated component [4].…”

“…Amongst the morphotypes of colorectal adenocarcinomas, the rich cell type of Paneth constitutes a rare histo-pathological variant of adenocarcinoma, which can be observed throughout digestive tract but also in other organs such as the prostate or breast [4].…”

“…About 25 cases were found in the literature, distributed evenly between the stomach (8 cases), the small intestine (7 cases) and the colon and appendix (7 cases). For the last three cases, the location is not specified [4]. The mean age of patients is 60 years with extremes of 30 and 89 years [4,[8], [9], [10], [11]].…”

“…For the last three cases, the location is not specified [4]. The mean age of patients is 60 years with extremes of 30 and 89 years [4,[8], [9], [10], [11]]. Clinical symptoms are not specific and even radiologic findings are similar to those observed in classic colonic adenocarcinoma.…”

“…Its occurrence in carcinomas is rarely reported in gastrointestinal system. Actually, Paneth cell carcinoma raising in a non-inflammatory colonic mucosa, is an exceptional event and to our knowledge, seven cases have been reported in the worldwide literature [4]. The little is known about the relationship between Paneth cell metaplasia and Paneth cell carcinoma nor have any precursor lesions been described [[5], [6]].…”