Umbilical Serum Insulin-like growth Factor 1 (IGF-1) in Newborns: Effects of Gestational Age, Postnatal Age, and Nutrition

Büyükkayhan, Derya; Tanzer, Fatoş; Erselcan, Taner; Çınar, Ziynet; Yönem, Özlem

doi:10.1024/0300-9831.73.5.343

Cited by 12 publications

(8 citation statements)

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“…Both IGF-I [8,14] and insulin [25] are normally significantly correlated with body weight. However, other authors have described a negative and significant correlation between IGF-1 and weight [7]. The strict selection criteria followed in our study explains the absence of significant correlations between those parameters.…”

Section: Discussioncontrasting

confidence: 62%

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Gesteiro¹,

Bastida

Sánchez‐Muniz

2008

Eur J Pediatr

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Several endocrine regulators are implicated in the development of metabolic syndrome. The aim of our study was to assess normal ranges for glucose, growth hormone (GH), insulin-like growth factor-1 (IGF-1), cortisol, insulin and the yet-to-be-published quantitative insulin sensitivity check index (QUICKI) for newborns and a number of homeostatic model assessment (HOMA)-related equations that have been proposed as indicators of insulin sensitivity (HOMA-S) and insulin resistance (HOMA-R). The study included 115 (54 males, 61 females) singleton, normoweight, Spanish Caucasian neonates delivered without foetal distress from mothers of the Mérida (Spain) Birth Cohort who tested negative in the O'Sullivan screen. Neonatal normal values given as the mean (95% confidence interval) were: glucose, 75.3 mg/dL (68.29-82.29); cortisol, 7.4 microg/dL (6.85-7.97); GH, 16.7 ng/mL (14.87-18.60); insulin, 5.5 microUI/mL (4.12-6.88), IGF-155.2 ng/mL (50.82-59.53); QUICKI, 0.45 (0.43-0.48); HOMA-R, 1.36 (0.84-1.88); HOMA-S, 4.07 (2.66-5.49), the glucose/insulin ratio, 33.6 (24.58-42.67); the insulin/cortisol ratio, 0.8 (0.61-1.05). Hormone ranges (except for cortisol, whose values were lower) were equivalent to those of other studies. Cortisolaemia values cannot be associated with the type of delivery, as only three births (2.6%) were by caesarean section, while 20 (17.4%) were instrumental deliveries. Neonates from the lowest quartile of the insulin/cortisol ratio presented higher (p < 0.001) HOMA-S and QUICKI and lower (p < 0.01) HOMA-R values. The results of our study indicate normal ranges for insulin resistance and sensitivity at birth. The insulin/cortisol ratio at birth appears to be a good early indicator of insulin resistance.

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Section: Discussioncontrasting

confidence: 62%

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Gesteiro¹,

Bastida

Sánchez‐Muniz

2008

Eur J Pediatr

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“…HM contains insulin-like growth factor-I (IGF-I), which is higher in colostrum than mature milk and higher in HM than bovine milk [ 70 ]. IGF-I is thought to be efficiently absorbed in the infant’s gastrointestinal tract and to increase in the serum post-feeding [ 71 ]. This growth factor is known to be involved in the development and growth of the infant via direct effects on cell differentiation and proliferation [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Human Milk Cells Contain Numerous miRNAs that May Change with Milk Removal and Regulate Multiple Physiological Processes

Alsaweed

Lai

Hartmann

et al. 2016

IJMS

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Human milk (HM) is a complex biofluid conferring nutritional, protective and developmental components for optimal infant growth. Amongst these are maternal cells, which change in response to feeding and were recently shown to be a rich source of miRNAs. We used next generation sequencing to characterize the cellular miRNA profile of HM collected before and after feeding. HM cells conserved higher miRNA content than the lipid and skim HM fractions or other body fluids, in accordance with previous studies. In total, 1467 known mature and 1996 novel miRNAs were identified, with 89 high-confidence novel miRNAs. HM cell content was higher post-feeding (p < 0.05), and was positively associated with total miRNA content (p = 0.014) and species number (p < 0.001). This coincided with upregulation of 29 known and 2 novel miRNAs, and downregulation of 4 known and 1 novel miRNAs post-feeding, but no statistically significant change in expression was found for the remaining miRNAs. These findings suggest that feeding may influence the miRNA content of HM cells. The most highly and differentially expressed miRNAs were key regulators of milk components, with potential diagnostic value in lactation performance. They are also involved in the control of body fluid balance, thirst, appetite, immune response, and development, implicating their functional significance for the infant.

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“…57 Breastfed infants have higher circulating IGF-I in the serum. 61 IGF can be taken up in a bioactive form by intestines, and transported into the blood. 54,62 The function of absorbed IGF has not been fully detailed, but enteral administration of physiological levels of IGF-I stimulates erythropoiesis and increases hematocrit.…”

Section: Growth Factorsmentioning

confidence: 99%

Human Milk Composition

Ballard¹,

Morrow²

2013

Pediatric Clinics of North America

1,851

922

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Synopsis The composition of human milk is the biologic norm for infant nutrition. Human milk also contains many hundreds to thousands of distinct bioactive molecules that protect against infection and inflammation and contribute to immune maturation, organ development, and healthy microbial colonization. Some of these molecules, e.g., lactoferrin, are being investigated as novel therapeutic agents. A dynamic, bioactive fluid, human milk changes in composition from colostrum to late lactation, and varies within feeds, diurnally, and between mothers. Feeding infants with expressed human milk is increasing. Pasteurized donor milk is now commonly provided to high risk infants and most mothers in the U.S. express and freeze their milk at some point in lactation for future infant feedings. Many milk proteins are degraded by heat treatment and freeze-thaw cycles may not have the same bioactivity after undergoing these treatments. This article provides an overview of the composition of human milk, sources of its variation, and its clinical relevance.

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Umbilical Serum Insulin-like growth Factor 1 (IGF-1) in Newborns: Effects of Gestational Age, Postnatal Age, and Nutrition

Abstract: These findings suggest that IGF-1 levels during the neonatal period are influenced by gestational age, birth weight, and nutrition.

Cited by 12 publications

References 0 publications

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Human Milk Cells Contain Numerous miRNAs that May Change with Milk Removal and Regulate Multiple Physiological Processes

Human Milk Composition

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