Umbilical Nodule Metastasis from Unknown Primary: Diagnostic and Therapeutic Dilemma

Gupta, Sweety; Sharma, Gaurav; Sharma, Nidhi; Mandal, Shreyosi; Gupta, Amit; Gupta, Manoj Kumar

doi:10.1055/s-0042-1749423

Cited by 5 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…*The age of the studied patients was (62.32±7.82) years, The majority of them were males (72%) and (64%) of them were smokers. Also, our results showed that the most common presenting symptoms were jaundice in 33 (66%) of patients followed by abdominal pain in 11(22%) patients and 5 patients accidentally discovered and 1 patient presented with abdominal swelling as shown in table(2).As regards to laboratory investigation of the studied patients, our results showed that patients with pancreatic adenocarcinoma had elevated serum bilirubin (8.74 + 7.82), elevated serum ALT (69.31 + 66.78), serum CA 19.9 (163.55 + 186.18) and serum CEA (14.56 + 18.54) as showed in table(3).…”

supporting

confidence: 51%

See 1 more Smart Citation

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

El-Nady

Hassan

Haridy

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: computed tomography (CT) of the abdomen with contrast is the gold standard method for the evaluation of pancreatic cancer concerning staging and vascular assessment. however, not all patients can be evaluated by contrast-enhanced CT abdomen as those with an allergy to the contrast agent, pregnancy, and renal impairment, in addition to hazards of radiation and non-availability of tissue sampling in CECT abdomen .so this study was designed to evaluate the diagnostic ability of Endoscopic Ultrasound for staging and vascular assessment of pancreatic cancer in comparison to CT abdomen with contrast. Method: fifty patients with cancer pancreas were evaluated by CECT and EUS as regard staging and vascular invasion. The vascular assessment was done by dividing the EUS findings into three types by the relationship between tumors and major vessels, type 1, clear invasion, encasement of the vessel by a tumor or tumor that contacts a vessel wall more than 180o; type2, Abutment, a tumor that contacts a vessel wall but less than 180o and type 3, clear non-invasion, the existence of distance between a tumor and a vessel. We regarded type 1 and type 2 as signs of vascular invasion and type 3 as a sign of vascular non-invasion, these findings were compared with the findings of the CECT abdomen. The endoscopist was blind to the CT result before the EUS examination. Result: as regards staging of pancreatic cancer EUS showed sensitivity, specificity, and accuracy of 100% for all. and as regard vascular invasion EUS showed sensitivity, specificity, and accuracy of 100%,95.93%, and 96% respectively for venous invasion and 95.65%,100%, and 99.5% for arterial invasion. Conclusion: EUS can evaluate staging and vascular invasion of pancreatic cancer with very high sensitivity, specificity, and accuracy to the extent it can replace CT in evaluation, with the superiority of EUS due to tissue sampling.

show abstract

supporting

confidence: 51%

“…Five-year survival rate doesn't exceed 10% 1 . It is the sixth most common cancer and the third cause of cancer-related deaths in the USA and the seventh leading cause worldwide 2 .…”

mentioning

confidence: 99%

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

El-Nady

Hassan

Haridy

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Various analytical techniques allow for better differentiation and quantification of metabolites in bodily fluids which may be good candidates for diagnosing and monitoring stroke. A proton nuclear magnetic resonance metabolomics study in rats showed that the levels of 23 metabolites are altered significantly including amino acids and neurometabolites such as N-acetyl aspartate, glutamate, glutamine, myo-inositol, and adenosine diphosphate (S. Gupta et al, 2020).…”

Section: Outcome and Severity Prediction Following Strokementioning

confidence: 99%

Biochemical, biomechanical and imaging biomarkers of ischemic stroke: Time for integrative thinking

Erdoğan,

Arpak,

Keles

et al. 2024

Eur J of Neuroscience

View full text Add to dashboard Cite

Stroke is one of the leading causes of adult disability affecting millions of people worldwide. Post‐stroke cognitive and motor impairments diminish quality of life and functional independence. There is an increased risk of having a second stroke and developing secondary conditions with long‐term social and economic impacts. With increasing number of stroke incidents, shortage of medical professionals and limited budgets, health services are struggling to provide a care that can break the vicious cycle of stroke. Effective post‐stroke recovery hinges on holistic, integrative and personalized care starting from improved diagnosis and treatment in clinics to continuous rehabilitation and support in the community. To improve stroke care pathways, there have been growing efforts in discovering biomarkers that can provide valuable insights into the neural, physiological and biomechanical consequences of stroke and how patients respond to new interventions. In this review paper, we aim to summarize recent biomarker discovery research focusing on three modalities (brain imaging, blood sampling and gait assessments), look at some established and forthcoming biomarkers, and discuss their usefulness and complementarity within the context of comprehensive stroke care. We also emphasize the importance of biomarker guided personalized interventions to enhance stroke treatment and post‐stroke recovery.

show abstract

“…Pancreatic cancer stands as a malignancy characterized by a dismal prognosis, boasting a mere five-year survival rate that scarcely surpasses 10% [ 1 ]. Globally, it ranks as the sixth most prevalent cancer and constitutes the third principal cause of cancer-induced mortality in the United States, further attesting to its profound impact [ 2 ]. The potential for curative intervention lies primarily in surgical resection with sufficient safety margins when metastatic lesions are absent.…”

Section: Introductionmentioning

confidence: 99%

Role of Endoscopic Ultrasound in Staging and Vascular Assessment of Pancreatic Cancer

El-Nady,

Ead,

Haridy

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction Computed tomography (CT) of the abdomen with contrast stands as the gold standard for assessing pancreatic cancer, encompassing both staging and vascular analysis. However, not all patients are suitable candidates for contrast-enhanced CT (CECT) scans due to factors such as contrast agent allergies, pregnancy, renal impairment, radiation risks, and limited tissue sampling capability in CECT scans of the abdomen. In light of these challenges, this study evaluated the diagnostic capabilities of endoscopic ultrasound (EUS) compared to CECT for staging and vascular assessment of pancreatic cancer. Methods Fifty patients diagnosed with pancreatic cancer underwent evaluations using both CECT scans and EUS, focusing on staging and vascular invasion assessment. Vascular evaluation was carried out using a categorization system based on EUS findings, classifying them into three types based on the tumor-vessel relationship: Type 1 indicating clear invasion or encasement of a vessel by a tumor or contact with a vessel wall exceeding 180 degrees, Type 2 representing abutment, wherein a tumor contacts a vessel wall but at an angle less than 180 degrees, and Type 3 implying clear non-invasion, where a discernible distance exists between a tumor and a vessel. In this categorization, Type 1 and Type 2 indicated signs of vascular invasion, while Type 3 indicated vascular non-invasion. These findings were subsequently compared to the results from CECT scans. The endoscopist performing EUS was blinded to the CT outcomes prior to the examination. Results Regarding pancreatic cancer staging, EUS exhibited remarkable sensitivity, specificity, and accuracy rates of 100% according to the T criterion.As for vascular invasion assessment, EUS demonstrated sensitivity, specificity, and accuracy of 100%, 95.93%, and 96%, respectively, for venous invasion. For arterial invasion, the figures were 95.65% sensitivity, 100% specificity, and an overall accuracy of 99.5%. Conclusion EUS is an effective modality for evaluating both staging and vascular invasion in pancreatic cancer, boasting exceptional sensitivity, specificity, and accuracy rates. The findings are robust enough to consider EUS a viable alternative to CT scans in evaluation, with the added advantage of EUS offering tissue sampling capability.

show abstract

Umbilical Nodule Metastasis from Unknown Primary: Diagnostic and Therapeutic Dilemma

Cited by 5 publications

References 22 publications

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

Role of endoscopic ultrasound in staging and vascular assessment of pancreatic cancer

Biochemical, biomechanical and imaging biomarkers of ischemic stroke: Time for integrative thinking

Role of Endoscopic Ultrasound in Staging and Vascular Assessment of Pancreatic Cancer

Contact Info

Product

Resources

About