Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Liska, Jiri; Holecek, Vaclav; Siala, Konrad; Sobotova, Stepanka; Trefil, Ladislav; Ráček, Jaroslav; Sýkora, Josef; Sefrna, Franstisek

doi:10.2174/1871522216666161018145434

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, on the basis of a polygenic foundation there is a possibility of sensitization of the fetus from the twentieth week of pregnancy through increased production of IgE, IL-4 and IL-5. Newborns also have an immaturely developed mucosal barrier which presents another entry point for potential allergens [ 3 , 8 , 10 , 11 , 17 , 18 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

10-year experience with umbilical cord blood IgE and microbiome therapy

Liska¹,

Siala²,

Blanka³

et al. 2019

Ital J Pediatr

Self Cite

View full text Add to dashboard Cite

BackgroundThe benefit of probiotics in newborn children in relation to allergy and general morbidity later in life appears to be controversial. Allergic diseases represent an increasingly important health problem worldwide in recent years. This is evident in all age groups. The occurrence of allergic illnesses also continues to rise exponentially, and thus the use of preventive and prognostic methods, particularly in children with an inherently higher risk of allergy, is gaining increased importance.Since the advent of probiotics the effect of probiosis on immunity through alterations of composition and function of the human gut microbiome has been increasingly studied. The exact mechanisms have not yet been clearly defined.The Academy of Sciences of the Czech Republic (The Czech Academy of Sciences has suggested that the expression of TH1 and TH2 cytokines in umbilical blood is associated with an increased risk of allergies. The counter -balance of Th1 and Th2 affect Immunoglobulin E (IgE) production and maturation of the gastrointestinal tract epithelium.Case presentationWe examined IgE levels in 3000 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 2007 to 2017.At the age of ten days, those with high IgE were given Colinfant Newborn (a lyophilized non-pathogenic strain of Escherichia.coli) for one month, three times weekly. At 15 months and three years we investigated the levels of Immunoglobulins E,A and G, and the incidence of illness and allergy.The results revealed that allergy and high umbilical IgE is strongly linked with family history (p ≤ 0.001). We also detected differences in seasonality, especially with regards to pollen allergies. Eighty percent of children treated with Colinfant Newborn had significantly reduced IgE and morbidity at 13–15 months and 3 years, and furthermore without any clinical signs of allergy. Normalization of Immunoglobulins A and G was seen in 90% of treated subjects (p ≤ 0.001). These levels significantly correlated with an almost negligible morbidity up to 4 years of life.Colinfant Newborn, a lyophilized strain of Esherichia coli (E. coli), and a normal component of intestinal flora, readily colonizes the intestinal tract. It’s long term presence significantly stimulates the production of specific and non-specific intestinal antibodies. and optimalizes immune development through tolerance. In our study Colinfant Newborn reduced the incidence of infections later in life by safely and effectively normalizing immunoglobulin levels in the majority of treated patients.ConclusionOur study strongly suggests as positive effect of physiological Escherichia coli on the microbiome of newborn children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life. These benefits appear to be strongly strain specific.

show abstract

Section: Discussionmentioning

confidence: 99%

10-year experience with umbilical cord blood IgE and microbiome therapy

Liska¹,

Siala²,

Blanka³

et al. 2019

Ital J Pediatr

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, on the basis of a polygenic foundation there is a possibility of sensitization of the fetus from the twenty second week of pregnancy through increased production of IgE, IL4 and IL5. Newborns also have an immaturely developed mucosal barrier which presents another entry point for potential allergens [3,8,10,11].…”

Section: Discussionmentioning

confidence: 99%

“…In our previously published study we demonstrated that neonates born to parents with allergies had increased levels of AGEs (advanced glycation end products) in their umbilical cord blood [11]. AGEs activate long lasting inflammation, followed by free radical production via NF kappaB formation.…”

mentioning

confidence: 96%

Significance of Immunoglobulin E in Umbilical Blood in Relation to an Allergic Family History, Seasonality, Child Immunity and the Impact of Applied Non-pathogenic E. coli on Children’s Microbiome

Liska¹,

Siala²,

Blanka³

et al. 2017

JLS

View full text Add to dashboard Cite

Abstract:We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age of ten days, those with high IgE were given Colinfant Newborn (a lyophilized non-pathogenic strain of E. coli) for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history (p ≤ 0.001). We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects (p ≤ 0.001). These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.

show abstract

Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Cited by 2 publications

References 0 publications

10-year experience with umbilical cord blood IgE and microbiome therapy

10-year experience with umbilical cord blood IgE and microbiome therapy

Significance of Immunoglobulin E in Umbilical Blood in Relation to an Allergic Family History, Seasonality, Child Immunity and the Impact of Applied Non-pathogenic E. coli on Children’s Microbiome

Contact Info

Product

Resources

About