Umbilical cord pH, Pco2, and bicarbonate following uncomplicated term vaginal deliveries

Yeomans, Edward R.; Hauth, John C.; Gilstrap, Larry C.; Strickland, Daniel

doi:10.1016/0002-9378(85)90523-x

Cited by 119 publications

(63 citation statements)

References 13 publications

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“…These levels were consistent with chronic asphyxia. In the control group, our findings supported the results presented in previous studies [19] [20].…”

Section: Discussıonsupporting

confidence: 92%

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Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

Karaca¹,

Bolluk²,

Akpak³

et al. 2015

OJOG

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Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, the other 20 patients had normal umbilical and uterine artery doppler waveforms. After the delivery, blood samples were taken from umbilical artery of double clemped umbilical cord for blood gas parameters, EPO and CD33 levels. Sociodemographic findings, antepartum, intrapartum test results, labor and delivery characteristics and newborn examination results were recorded. Blood gas parameters, EPO and CD33 levels between groups were analyzed. Mann-Whitney U test and t-test were used as statistical methods. Results: There were no differences between parity, gestational ages and newborn weights of the groups. Cord blood CD33 and EPO levels of group with abnormal umbilical and uterine artery doppler waveforms were significantly higher than group with normal umbilical and uterine artery doppler waveforms (p < 0.01). Conclusion: Pathology on doppler screen shows to us a connection between chronic hypoxemia and abnormal on doppler screen. Preference of high blood CD33 levels for cord blood transplantation especially during last years can also be used with preference of cord blood with abnormal doppler findings. * Corresponding author. N. Karaca et al.235

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“…These levels were consistent with chronic asphyxia. In the control group, our findings supported the results presented in previous studies [19] [20].…”

Section: Discussıonsupporting

confidence: 92%

“…It implies a dysfunction resulting from a lack of oxygen supply to the baby's tissues during the birth process. The most important and reliable method to make the diagnosis is cord blood acid-base analysis [18] [19]. In our study, umbilical arterial blood was collected for gas analysis.…”

Section: Discussıonmentioning

confidence: 99%

Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

Karaca¹,

Bolluk²,

Akpak³

et al. 2015

OJOG

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show abstract

“…The protocol was explained to all the patients in detail in their own language and informed consent taken. Prospective power analysis was based on potential differences in umbilical cord blood gases using data from normal deliveries [18]. This showed that a sample size of 22 patients per group would have 90% power at the 5% significance level to detect a difference in umbilical arterial pH of 0.05 units.…”

Section: Methodsmentioning

confidence: 99%

Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section

Kansal¹,

Mohta

Sethi³

et al. 2004

Anaesthesia

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SummaryThis study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of ‡ 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section.

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“…Andres et al (1999) suggested that pathologic fetal acidemia should be pH < 7.0 in arterial blood with a metabolic component. On the other hand, several authors defined significant acidemia as the range of pH from 7.10 to 7.18 that is 2 standard deviations below the mean for a given population (Yeomans et al 1985;Ruth and Raivio 1988). These reports and definitions utilize a low pH compared with the arterial pH 7.183 that experimentally was associated with appearance of spikes.…”

Section: Discussionmentioning

confidence: 99%

Appearance of Abnormal Electrocorticogram Patterns during Umbilical Cord Compression in Sheep Fetus

Takahashi

Sugawara

Chisaka

et al. 2006

Tohoku J. Exp. Med.

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A frequent cause of fetal acidemia, which sometimes results in hypoxic-ischemic encephalopathy, is umbilical cord compression associated with uterine contraction. Using a sheep model of fetal acidemia, we examined the changes in electrocorticogram (ECoG), carotid artery blood flow, arterial blood pressure and fetal heart rate during cord compression. A characteristic burst of ECoG spikes emerged during cord compression at fetal arterial pH 7.18 even before the pH went down to severe fetal acidemia (less than 7.10). The administration of a neuromuscular blocking agent to the fetus did not abolish the appearance of the spikes. These results suggest that cord compression may cause abnormal brain excitement even in the absence of severe fetal acidemia and that this abnormal excitement can lead to fetal brain dysfunction, if cord compression is repeated or prolonged.fetal heart rate; cord compression; fetal electrocorticogram; fetal acidemia

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Umbilical cord pH, Pco2, and bicarbonate following uncomplicated term vaginal deliveries

Cited by 119 publications

References 13 publications

Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section

Appearance of Abnormal Electrocorticogram Patterns during Umbilical Cord Compression in Sheep Fetus

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