2011
DOI: 10.2174/1875043501104010112
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Umbilical Cord Perivascular Cells: A Mesenchymal Cell Source for Treatment of Tendon Injuries

Abstract: Abstract:Objective: To model the healing that umbilical cord perivascular cells effect in equines, we have used human umbilical cord perivascular cells (HUCPVCs) to repair tendon damage in a collagenase tendon injury model in immunecompromised rats. Animals: 48 Nude rats (Crl:NIH-Foxn1 rnu ) of 200-250 g weight were used. Procedure: The Achilles tendon was exposed by blunt dissection and, using a 30G needle, 30 µl of either a mixture of cells (2 x10 5 ) and collagenase, or collagenase alone, was injected close… Show more

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Cited by 15 publications
(11 citation statements)
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“…Human MSCs derived from embryonic and fetal sources have also exhibited the ability to enhance cardiomyogenesis compared with their adult counterparts [17]. Moreover, several reports have recently demonstrated the regenerative potential of HUCPVCs in different animal models [18][19][20]. Taken together, these data support the use of HUCPVCs as a more homogeneous source of stromal progenitors and potentially more useful for cell replacement therapy, or more likely, in better stimulating the endogenous recovery of injured tissue.…”
Section: Resultsmentioning
confidence: 72%
“…Human MSCs derived from embryonic and fetal sources have also exhibited the ability to enhance cardiomyogenesis compared with their adult counterparts [17]. Moreover, several reports have recently demonstrated the regenerative potential of HUCPVCs in different animal models [18][19][20]. Taken together, these data support the use of HUCPVCs as a more homogeneous source of stromal progenitors and potentially more useful for cell replacement therapy, or more likely, in better stimulating the endogenous recovery of injured tissue.…”
Section: Resultsmentioning
confidence: 72%
“…Human umbilical cord perivascular cells (HUCPVCs) have been shown to produce collagen that repairs tendon injuries in rats [35]. Additionally, the presence of HUCPVCs facilitated a change in structure and organization of the collagen fibers [35].…”
Section: Cell Therapy For Cardiovascular and Connective Tissue Repairmentioning
confidence: 99%
“…Emrani and Davies [20] propose an experimental protocol for the use of perivascular MSC (HUCPVC) from human umbilical cord to treat tendon injuries in a rat model. The authors demonstrate that the infused cells improve regeneration in the model used via collagen reorganization and tensile properties variation, thus suggesting the utility of such cells for tendon regeneration and repair.…”
Section: Breymann and Semonovmentioning
confidence: 99%