Umbilical Cord Mesenchymal Stem Cells Suppress Host Rejection

Coulson‐Thomas, Vivien Jane; Gesteira, Tarsis F.; Hascall, Vincent C.; Kao, Winston W.‐Y.

doi:10.1074/jbc.m114.557447

Cited by 76 publications

(88 citation statements)

References 47 publications

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“…However, we have recently shown that UMSCs have unique immunosuppressive properties that can prevent xenograft rejection, making these cells extremely attractive for cell therapy. 27 Our study demonstrated that UMSCs actively regulate immune cells, inhibiting M1 polarization and promoting M2 polarization in an extracellular matrix-dependent manner.…”

Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 62%

“…26 In the case of T cells, MSCs primarily promote the activation of T regulatory cells. 27,28 In the case of B cells, MSCs inhibit B-cell proliferation, plasma-cell differentiation, and antibody production, all in a T-cell-dependent manner. 29 To date, MSCs have been shown to regulate the innate and adaptive immune responses primarily in a cytokine-dependent manner through the secretion of transforming growth factor-beta ( TGFβ ), interferon gamma ( IFNγ ), prostaglandin E2 ( PGE2 ), interleukin ( IL )-10 and tumor necrosis factor-alpha ( TNFα ).…”

Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 99%

“…We have recently demonstrated that UMSCs secrete a specific ECM that is composed of hyaluronan ( HA ), heavy chains ( HC s), tumor necrosis factor-inducible gene 6 protein ( TSG-6 ), and pentraxin 3 ( PTX3/TSG14 ). 27 (See Figure 2.) This specific glycocalyx inhibits the maturation of M1 macrophages and promotes the maturation of both M2 macrophages and T-regulatory cells.…”

Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 99%

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Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

et al. 2016

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Mesenchymal stem cells (MSCs) are a group of fibroblast-like multipotent mesenchymal stromal cells that have the ability to differentiate into osteoblasts, adipocytes, and chondrocytes. Recent studies have demonstrated that MSCs possess a unique ability to exert suppressive and regulatory effects on both adaptive and innate immunity in an autologous and allogeneic manner. A vital step in stem cell transplantation is overcoming the potential graft-versus-host disease, which is a limiting factor to transplantation success. Given that MSCs attain powerful differentiation capabilities and also present immunosuppressive properties, which enable them to survive host immune rejection, MSCs are of great interest. Due to their ability to differentiate into different cell types and to suppress and modulate the immune system, MSCs are being developed for treating a plethora of diseases, including immune disorders. Moreover, in recent years, MSCs have been genetically engineered to treat and sometimes even cure some diseases, and the use of MSCs for cell therapy presents new perspectives for overcoming tissue rejection. In this review, we discuss the potential extrinsic and intrinsic mechanisms that underlie MSCs’ unique ability to modulate inflammation, and both innate and adaptive immunity.

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Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 62%

Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Section: Immunosuppressive Properties Of Mesenchymal Stem Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

et al. 2016

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“…It is also interesting to know that Coulson-Thomas et al (46) have recently demonstrated that MSCs from umbilical cord express a rich glycocalyx composed of the chondroitin sulfate proteoglycan versican bound to the SHAP-HA complex and could modulate inflammatory cells to reduce the immune response and suppress rejection. This mechanism might be operative in part for the settlement of MSCs transplanted in the damaged muscle and for that of MSCs injected in the intact muscle after activation by the C2C12 lysate, which we observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Acute and Temporal Expression of Tumor Necrosis Factor (TNF)-α-stimulated Gene 6 Product, TSG6, in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successful Transplantation into Muscle Tissue

Torihashi

Kawakubo

et al. 2015

Journal of Biological Chemistry

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Background:Transplanted MSCs cannot settle in intact muscles. Results: When MSCs release TSG6 in the intact muscle, they can settle after transplantation. TSG6 forms the SHAP-hyaluronan complex with hyaluronan and I␣I. Conclusion: TSG6, hyaluronan, and I␣I are crucial factors forming footholds for the settlement and differentiation of MSCs. Significance: TSG6, hyaluronan, and I␣I serve for improvement of regenerative medicine.

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“…It is not consensual if allogeneic delivery of MSCs would lead to immune rejection. Actually, many findings with somatic stem cells showed that they possess immunossupressive action, not being rejected by the host organism [99][100][101][102] . If lack of immune rejection becomes confirmed for allogeneic somatic stem cell transplants, this would certainly represent the preferred option, making it possible that cultured cells are readily available for the patients.…”

Section: Stem Cell Types and Clinical Applications: An Everemerging Smentioning

confidence: 99%

Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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Intracerebral hemorrhage (ICH) is a very complex pathology, with many different not fully elucidated etiologies and prognostics. It is the most severe subtype of stroke, with high mortality and morbidity rates. Unfortunately, despite the numerous promising preclinical assays including neuroprotective, anti-hypertensive, and anti-inflammatory drugs, to this moment only symptomatic treatments are available, motivating the search for new alternatives. In this context, stem cell therapy emerged as a promising tool. However, more than a decade has passed, and there is still much to be learned not only about stem cells, but also about ICH itself, and how these two pieces come together. To date, rats have been the most widely used animal model in this research field, and there is much more to be learned from and about them. In this review, we first summarize ICH epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts. Core tip: In this review, we first summarize intracerebral hemorrhage (ICH) epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.Cordeiro MF, Horn AP. Stem cell therapy in intracerebral hemorrhage rat model. World J Stem Cells 2015; 7(3): 618-629

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Umbilical Cord Mesenchymal Stem Cells Suppress Host Rejection

Cited by 76 publications

References 47 publications

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

Acute and Temporal Expression of Tumor Necrosis Factor (TNF)-α-stimulated Gene 6 Product, TSG6, in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successful Transplantation into Muscle Tissue

Stem cell therapy in intracerebral hemorrhage rat model

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