Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence

Meir, Anat Yaskolka; Huang, Wanyu; Cao, Tingyi; Hong, Xiumei; Wang, Guoying; Pearson, Colleen; Adams, William; Wang, Xiaobin; Liang, Liming

doi:10.1016/j.ebiom.2023.104550

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…For example, previous metabolomics studies of cord blood showed metabolic derangement predisposes newborns to cardiometabolic and endocrine diseases, and disrupt the normal hormone function and neonatal adiposity 82,89 . Previous epigenome-wide association study (EWAS) with cord blood found a strong association between DNA methylation pattern and postnatal BMI trajectory until adolescent 90 .…”

Section: Discussionmentioning

confidence: 97%

Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre-Pregnancy Obesity

Du,

Benny,

Shao

et al. 2024

Preprint

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Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the transgenerational effect of maternal obesity, we conducted a multi-omics study, using DNA methylation and gene expression in the CD34+/CD38-/Lin- umbilical cord blood hematopoietic stem cells (uHSCs) and metabolomics of the cord blood, all from a multi-ethnic cohort (n=72) from Kapiolani Medical Center for Women and Children in Honolulu, Hawaii (collected between 2016 and 2018). Differential methylation (DM) analysis unveiled a global hypermethylation pattern in the maternal pre-pregnancy obese group (BH adjusted p<0.05), after adjusting for major clinical confounders. Comprehensive functional analysis showed hypermethylation in promoters of genes involved in cell cycle, protein synthesis, immune signaling, and lipid metabolism. Utilizing Shannon entropy on uHSCs methylation, we discerned notably higher quiescence of uHSCs impacted by maternal obesity. Additionally, the integration of multi-omics data-including methylation, gene expression, and metabolomics-provided further evidence of dysfunctions in adipogenesis, erythropoietin production, cell differentiation, and DNA repair, aligning with the findings at the epigenetic level. This study reveals the significant correlation between pre-pregnancy maternal obesity and multi-omics level molecular changes in the uHSCs of offspring, particularly in DNA methylation.

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Section: Discussionmentioning

confidence: 97%

Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre-Pregnancy Obesity

Du,

Benny,

Shao

et al. 2024

Preprint

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Maternal obesity and placental function: impaired maternal–fetal axis

Louwen,

Kreis,

Ritter

et al. 2024

Arch Gynecol Obstet

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The prevalence of maternal obesity rapidly increases, which represents a major public health concern worldwide. Maternal obesity is characteristic by metabolic dysfunction and chronic inflammation. It is associated with health problems in both mother and offspring. Increasing evidence indicates that the placenta is an axis connecting maternal obesity with poor outcomes in the offspring. In this brief review, we have summarized the current data regarding deregulated placental function in maternal obesity. The data show that maternal obesity induces numerous placental defects, including lipid and glucose metabolism, stress response, inflammation, immune regulation and epigenetics. These placental defects affect each other and result in a stressful intrauterine environment, which transduces and mediates the adverse effects of maternal obesity to the fetus. Further investigations are required to explore the exact molecular alterations in the placenta in maternal obesity, which may pave the way to develop specific interventions for preventing epigenetic and metabolic programming in the fetus.

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Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity

Waldrop,

Sauder,

Niemiec

et al. 2024

Epigenomics

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Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence

Cited by 5 publications

References 54 publications

Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre-Pregnancy Obesity

Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre-Pregnancy Obesity

Maternal obesity and placental function: impaired maternal–fetal axis

Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity

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