Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Sanchez‐Petitto, Gabriela; Rezvani, Katayoun; Daher, May; Rafei, Hind; Kebriaei, Partow; Shpall, Elizabeth J.; Olson, Amanda

doi:10.1093/stcltm/szac086

Cited by 15 publications

(7 citation statements)

References 129 publications

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“…Table (1): displays socio-demographic characteristics of the studied pregnant women. As regard to women's age, it was observed that more than half (58.1%) of the studied women their age was (25 to 35) and slightly less than one third (30.7%) their age was 15 and less than <25.…”

Section: Resultsmentioning

confidence: 99%

“…Today, one of the main sources of hematopoietic stem cells is cord blood. The placenta and umbilical cord of newborn infants contain umbilical cord blood, commonly known as cord blood (1) . The umbilical cord is the cord that connects the baby to the placenta.…”

Section: Introductionmentioning

confidence: 99%

“…Similar to bone marrow and peripheral blood, umbilical cord blood is a rich source of stem cells for transplantation. The use of cord blood may be advantageous for some people (1,6) . Umbilical cord Blood banking is a relatively new technique gaining popularity in the past 30 years.…”

Section: Introductionmentioning

confidence: 99%

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Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Awad,

EL-Said,

Khaton

2023

Tanta Scientific Nursing Journal

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Background: In the light of the increase in incidence of immunity diseases, metabolic disorders and blood diseases, the need for cord blood stem cell as therapeutic option has become essential. Parents, especially mothers need to decide if they would like to store their infant's cord blood and donate it. They need to be aware of options exists and information needed. Aim of the study was to assess pregnant women knowledge and attitudes toward cord blood stem cell banking and donation at Gharbia Governorate, Egypt. Setting: This study was conducted in Antenatal Clinics at the largest ten Central Hospitals and ten Rural Health Units in Gharbia Governorate, Egypt. Subjects: A convenient sample of one thousand (1000) pregnant women from the previous settings. Tools: Two tools were used: Tool I: Structured Interview Schedule: It included three parts: -Socio-demographic data of the pregnant women, obstetric history of the pregnant women and Pregnant Women's knowledge toward cord blood stem cells & its banking and donation. Tool II: Pregnant women' attitudes toward donation and banking of cord blood stem cells. Results: the majority (78.5%) of the studied pregnant women had low level of knowledge regarding cord blood and stem cell & its banking and donation and nearly the half (49.5%) of them had negative attitudes, with statistically significant relationship between total knowledge and attitudes scores. Education and occupation of the pregnant women have a statistically significant correlation with total knowledge and attitudes scores. Conclusion and recommendations: the levels of pregnant women knowledge and attitudes regarding cord blood stem cell banking and donation were very low and need to be improved. Therefore, it is recommended to conduct health education programs and companies through health authorities and the media to increase awareness and support pregnant women's positive attitudes toward cord blood stem cell banking and donation to develop and expand the status of umbilical cord blood banking in Egypt.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Awad,

EL-Said,

Khaton

2023

Tanta Scientific Nursing Journal

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“…Although this procedure is crucial to determine whether the filtration was efficient, or not, in minimizing the concentration of immunological cells in the RBC used for allogeneic applications, since these cells can induce graft-versus-host disease (GvHD) [18]. UCB lymphocytes were of the naïve type and led to low GvHD levels [19].…”

Section: Discussionmentioning

confidence: 99%

Using umbilical cord blood as a source of paediatric packed red blood cells: Processing and quality control

2023

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Background and ObjectivesUmbilical cord blood (UCB) has been used as a source of red blood cells (RBCs) for neonatal/paediatric transfusion purposes. This study adopted two different procedures to obtain umbilical RBC (U‐RBC) to compare its quality control parameters to those of fractionated adult RBC (A‐RBC), for paediatric purposes.Materials and MethodsUCB units (24) were filtered and processed based on two different methods, namely, conventional/manual (P1;n12) and automatic (P2;n12). They were compared to five fractionated A‐RBCs. U‐RBC and A‐RBC were stored for 14 days and had their haematological, biochemical, haemolytic and microbiological parameters analysed at D1, D7 and D14. Cytokines and growth factors (GFs) in residual U‐RBC plasma were measured.ResultsMean volume of processed U‐RBC units was 45 mL for P1 and 39 mL for P2; the mean haematocrit level reached 57% for P1 and 59% for P2. A‐RBC recorded a mean volume of 44 mL. Haematologic and biochemical parameters analysed in U‐RBC and A‐RBC presented similar behaviours during storage time, except for parameter values, which differed between them. Pro‐inflammatory and immunomodulatory cytokines, as well as GFs, were higher in U‐RBC residual plasma than in that A‐RBC.ConclusionUCB can be processed into RBC based on either manual or automated protocols. U‐RBC units met the referenced quality parameters defined for A‐RBC. Some features, mainly the biochemical ones, should be further investigated to help improve quality parameters, with emphasis on differences found in, and particularities of, this material and on recipients of this new transfusion practice.

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“…When sourcing HSC and HPC from UCB, grafts potentially benefit from inherent tissue primitiveness. As such, GVHD-contributing populations are rare, providing an important option that can partially circumvent such a transplant-related complication ( Sanchez-Petitto et al, 2023 ). For instance, incidence of chronic GVHD was seen to be significantly lower when UCB cells (5.8%) are used compared to mPB (10.1% - mismatched unrelated donor and 11.5% matched unrelated donor) in the therapeutic context of acute myeloid leukemia ( Malard et al, 2015 ).…”

Section: Sources Of Hsc and Hpc For Clinical Usementioning

confidence: 99%

Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

Branco,

Rayabaram,

Miranda

et al. 2024

Front. Bioeng. Biotechnol.

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As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply of differentiated populations that are responsible for critical bodily functions, including oxygen transport, immunological protection and coagulation. Due to the far-reaching influence of the hematopoietic system, hematological disorders typically have a significant impact on the lives of individuals, even becoming fatal. Hematopoietic cell transplantation was the first effective therapeutic avenue to treat such hematological diseases. Since then, key use and manipulation of hematopoietic stem cells for treatments has been aspired to fully take advantage of such an important cell population. Limited knowledge on hematopoietic stem cell behavior has motivated in-depth research into their biology. Efforts were able to uncover their native environment and characteristics during development and adult stages. Several signaling pathways at a cellular level have been mapped, providing insight into their machinery. Important dynamics of hematopoietic stem cell maintenance were begun to be understood with improved comprehension of their metabolism and progressive aging. These advances have provided a solid platform for the development of innovative strategies for the manipulation of hematopoietic stem cells. Specifically, expansion of the hematopoietic stem cell pool has triggered immense interest, gaining momentum. A wide range of approaches have sprouted, leading to a variety of expansion systems, from simpler small molecule-based strategies to complex biomimetic scaffolds. The recent approval of Omisirge, the first expanded hematopoietic stem and progenitor cell product, whose expansion platform is one of the earliest, is predictive of further successes that might arise soon. In order to guarantee the quality of these ex vivo manipulated cells, robust assays that measure cell function or potency need to be developed. Whether targeting hematopoietic engraftment, immunological differentiation potential or malignancy clearance, hematopoietic stem cells and their derivatives need efficient scaling of their therapeutic potency. In this review, we comprehensively view hematopoietic stem cells as therapeutic assets, going from fundamental to translational.

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Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Cited by 15 publications

References 129 publications

Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Pregnant Women' Knowledge and Attitudes toward Cord Blood Stem Cell Banking and Donation at Gharbia Governorate, Egypt

Using umbilical cord blood as a source of paediatric packed red blood cells: Processing and quality control

Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

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