Umbilical cord blood transplant in human

Gluckman, E.

doi:10.1007/s00282-996-0393-1

Cited by 14 publications

(17 citation statements)

References 26 publications

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“…In order to be used as a source of haematopoietic stem cells, UCB must be collected, processed and cryopreserved in biobanks. During the 1990s, national public UCB banks were established in increasing numbers, beginning in the US, France, the UK, Confidential Author Version -Pre-proof 2 Germany, Italy and Spain (Gluckman 1996). Nowadays, according to Bone Marrows Donor Worldwide, more than 600,000 UCB units are stored in public banks and other participating registries (BMDW 2015).…”

Section: Introductionmentioning

confidence: 99%

Hybrid practices in cord blood banking. Rethinking the commodification of human tissues in the bioeconomy

Hauskeller

Beltrame

2016

New Genetics and Society

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Abstract:The STS and bioethical literature on umbilical cord blood (UCB) banking nowadays discusses the field as divided into opposite institutional arrangements, public versus private banking. Public banks represent a model sharing economy, private banks a market economy that capitalizes hopes and tissues, and new hybrid forms that are emerging. We challenge that this distinction is analytically valuable for understanding the various forms of marketization, commodification and biovalue production that mark the UCB economy.Our analysis of current UCB banking practices, especially hybrid one's, and their inherent visions of the future, shows that hybrid UCB banking criss-crosses the different economic models and concepts of commodification. The private, public, hybrid distinction is thus inadequate for a critically analysis of the complex UCB bioeconomies. Drawing on the perspective of social welfare systems analysis, however, the tripartite distinction emphasises an important ethical and biopolitical commitment to equality in current and future health care.

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Section: Introductionmentioning

confidence: 99%

Hybrid practices in cord blood banking. Rethinking the commodification of human tissues in the bioeconomy

Hauskeller

Beltrame

2016

New Genetics and Society

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“…This discovery was confirmed and in 1988 the first successful transplant of UCB derived stem cells was performed (Gluckman et al, 1989). In order to manage the supply of this life-saving tissue, public UCB banks were established in the early 1990s in New York, Paris, London, Milan, Barcelona and Düsseldorf (Gluckman, 1996). Their repositories are connected through computer databases in international registries that permit the search for UCB units compatible with the patient's immune system for allogeneic transplantation (for example, the European Marrow Donor Information System and Bone Marrow Donor Worldwide).…”

Section: The Organization Of Ucb Biobanksmentioning

confidence: 99%

The hybrid bioeconomy of umbilical cord blood banking: Re-examining the narrative of opposition between public and private services

Hauskeller

Beltrame

2016

BioSocieties

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Umbilical cord blood (UCB) is an important source for stem cells used in clinical treatments. For this purpose, UCB has to be collected at birth and stored in biobanks. The discourse about UCB biobanking practices commonly holds that it occurs in two opposite economies, the public sector and a competing private one. They correspond with moral economies of gift-giving in a redistributive economy versus private ownership of cord blood in a market economy. Our analysis of UCB banking in Europe shows that this opposition narrative is both empirically and analytically unsatisfactory. Using the analytic concepts of entanglement (Callon) and biomedical platforms (Keating and Cambrosio), we demonstrate how the network of actors, objects, interests and practices in biobanking creates different kinds of value and shared issues across public and private services. Our case study illustrates how the interrelation between technical, ethical, economic and logistical considerations plays out and generates a field of practices where redistributive and market economies coexist, are co-dependent and hybridize each other. The narrative of opposition therefore can inform STS studies regarding the normative values written into the public facing side of biobanking, but bioeconomic analyses benefit from building on concepts that enable the examination of the complex interrelations between the wider network of heterogeneous elements on which UCB banking relies.

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“…14 Cord blood transplantation might give additional perspectives for those children for whom a suitable related or unrelated bone marrow donor could not be identified. 15 PBSC are gaining increasing acceptance as an alternative to bone marrow (BM)-derived stem cells for allografting from HLA-identical sibling donors and HLA mismatch family donors, respectively. 16,17 In some countries stimulation of healthy stem cell donors with cytokines is not allowed.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 When autologous stem cells are used the administration of chemotherapy and growth factors before PBSC harvesting seems to accelerate haematologic reconstitution. 21 Patients who received at least 3 × 10 6 /kg CD34 + cells achieved granulocyte reconstitution on day 11 after reinfusion (range [8][9][10][11][12][13][14][15] and an unsupported platelet count of 25 × 10 9 /l on day 14 (range 12-180), significantly earlier than patients who received fewer cells (P Ͻ 0.001). 22 Thus, efforts should be made to transplant high stem cell doses (Ͼ3 × 10 6 /kg recipient's body weight) both in the allogeneic and autologous setting.…”

Section: Discussionmentioning

confidence: 99%

Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases

Peters

Ladenstein

Minkov

et al. 1998

Bone Marrow Transplant

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Summary:To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85). On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year. Median four rooms/centre (range 1-17) were available for paediatric SCT. The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%. Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT. PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type. Keywords: stem cell transplantation; children; isolation rooms; staff; bone marrow harvesting; blood cell support Allogeneic (allo) and autologous (auto) stem cell transplants (SCT) are performed increasingly in children with malignancies, as well as with congenital or acquired haema-

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Umbilical cord blood transplant in human

Cited by 14 publications

References 26 publications

Hybrid practices in cord blood banking. Rethinking the commodification of human tissues in the bioeconomy

Hybrid practices in cord blood banking. Rethinking the commodification of human tissues in the bioeconomy

The hybrid bioeconomy of umbilical cord blood banking: Re-examining the narrative of opposition between public and private services

Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases

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