“…In this study we have used the pulsatility index (PI) and maximum (centre stream) velocity. PI is a quantification of the blood velocity waveform and is derived from the peak to peak amplitude of the waveform divided by the mean amplitude over the cardiac cycle (Gosling & King, 1974) and is directly proportional to downstream impedance to flow (Trudinger, 1987 …”
1. Human alpha calcitonin gene‐related peptide (h alpha CGRP) is a potent vasodilator which in doses up to 1.5 micrograms min‐1 i.v. produces little or no fall in blood pressure in normal volunteers, but does cause a substantial tachycardia. 2. We have explored the underlying mechanism of this effect by comparing h alpha CGRP infused so as to maintain heart rate 25‐30% above baseline with glyceryl trinitrate (GTN) in a dose sufficient to maintain a throbbing headache. 3. Ten normal volunteers were studied. In addition to blood pressure and heart rate, blood velocity and pulsatility index (PI) were determined from Doppler signals recorded from the internal and external carotid, renal and femoral arteries. 4. Following h alpha CGRP blood pressure (mean +/‐ s.d., mm Hg) did not significantly change: 120 +/‐ 10/70 +/‐ 7 before compared with 121 +/‐ 12/67 +/‐ 7 during h alpha CGRP infusion. Heart rate (mean +/‐ s.d., beats min‐1) increased from 62 +/‐ 8 to 86 +/‐ 10 (P less than 0.0001). In contrast the blood pressure fell following GTN: 124 +/‐ 12/74 +/‐ 8 before compared with 111 +/‐ 13/62 +/‐ 6 following treatment (P less than 0.02). Heart rate did not change following GTN: 64 +/‐ 9 compared with 69 +/‐ 10. 5. GTN significantly increased PI (mean +/‐ s.d.) in the common carotid artery from 2.8 +/‐ 0.5 to 3.4 +/‐ 0.5 (P less than 0.003) while h alpha CGRP increased PI in the internal carotid from 1.3 +/‐ 0.2 to 2.1 +/‐ 0.4 (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
“…In this study we have used the pulsatility index (PI) and maximum (centre stream) velocity. PI is a quantification of the blood velocity waveform and is derived from the peak to peak amplitude of the waveform divided by the mean amplitude over the cardiac cycle (Gosling & King, 1974) and is directly proportional to downstream impedance to flow (Trudinger, 1987 …”
1. Human alpha calcitonin gene‐related peptide (h alpha CGRP) is a potent vasodilator which in doses up to 1.5 micrograms min‐1 i.v. produces little or no fall in blood pressure in normal volunteers, but does cause a substantial tachycardia. 2. We have explored the underlying mechanism of this effect by comparing h alpha CGRP infused so as to maintain heart rate 25‐30% above baseline with glyceryl trinitrate (GTN) in a dose sufficient to maintain a throbbing headache. 3. Ten normal volunteers were studied. In addition to blood pressure and heart rate, blood velocity and pulsatility index (PI) were determined from Doppler signals recorded from the internal and external carotid, renal and femoral arteries. 4. Following h alpha CGRP blood pressure (mean +/‐ s.d., mm Hg) did not significantly change: 120 +/‐ 10/70 +/‐ 7 before compared with 121 +/‐ 12/67 +/‐ 7 during h alpha CGRP infusion. Heart rate (mean +/‐ s.d., beats min‐1) increased from 62 +/‐ 8 to 86 +/‐ 10 (P less than 0.0001). In contrast the blood pressure fell following GTN: 124 +/‐ 12/74 +/‐ 8 before compared with 111 +/‐ 13/62 +/‐ 6 following treatment (P less than 0.02). Heart rate did not change following GTN: 64 +/‐ 9 compared with 69 +/‐ 10. 5. GTN significantly increased PI (mean +/‐ s.d.) in the common carotid artery from 2.8 +/‐ 0.5 to 3.4 +/‐ 0.5 (P less than 0.003) while h alpha CGRP increased PI in the internal carotid from 1.3 +/‐ 0.2 to 2.1 +/‐ 0.4 (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
“…In addition, compromised pregnancies show a decrease in umbilical cord blood flow, which is due to a drop in umbilical blood flow velocity (51). Moreover, increased umbilical arterial pulsatility index and resistance index, which is contingent upon increased placental vascular resistance, are evident in both human and sheep compromised pregnancies (14,19,58). Low birth weight offspring from compromised pregnancies have increased incidences of adult onset diseases (6), poor growth rates, and lower daily rates of gross energy accretion (23).…”
Lemley CO, Meyer AM, Camacho LE, Neville TL, Newman DJ, Caton JS, Vonnahme KA. Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction.
“…In our case, SUA was clearly observed connect ing to left internal iliac artery. In addition, to discern which is artery or vein precisely, additional examination using color and pulsed Doppler ultrasonography is useful, because SUA is often larger than normal artery, equaling its diameter to that of umbilical vein [ 16], Since Trudinger and Cook [17] first reported the ante natal diagnosis of DUA in 1988, a few cases of DUA have been described antenately. Most anomalies of umbilical vessels have been confirmed after delivery, but the dis tinction of DUA is difficult under the drained and col lapsed umbilical cord after delivery.…”
Section: Discussionmentioning
confidence: 99%
“…Most anomalies of umbilical vessels have been confirmed after delivery, but the dis tinction of DUA is difficult under the drained and col lapsed umbilical cord after delivery. Moreover, most ba bies with DUA have no external anomalies [9,17,18]. Therefore, DUA might be missed unless close antenatal investigation with ultrasonography was carried out.…”
Objective: To evaluate the antenatal screening of aberrant umbilical vessels and assess the association of fetal abnormality with these entities. Study Design: 444 pregnant women were studied with routine obstetric ultrasound and Doppler color flow imaging in late second trimester or early third trimester. Fetal growth and anomaly, and the number of umbilical cord vessels were screened. Results: Out of 444 subjects, 3 cases with discordant umbilical artery, 2 with four vessels in the umbilical cord, and 1 with single umbilical artery were detected (1.4%). Fetal anomaly was noted in 2 of 6 cases with aberrant umbilical vessels (33.3%). Conclusion: These results suggest that antenatal screening of umbilical cord vessels is necessary for detection of fetal anomalies.
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