Umbilical artery aneurysm in a severe growth‐restricted fetus with normal karyotype

Large Umbilical Artery Aneurysm with a Live Healthy Baby Delivered at 31 Weeks

“…To date, there are only 2 cases reported with a normal karyotype [2] . Recognized complications of umbilical artery aneurysms include rupture, thrombosis, fetal growth re- striction and fetal death due to acute umbilical vein compression or thrombosis within the aneurysm [3,4] .…”

Umbilical Artery Aneurysm

“…Trisomy 18 is associated in 3 (23%) of the 13 cases. 5,6,8,9 There is no definitive evidence on the influence of a single umbilical artery on the development of an umbilical artery aneurysm. A single umbilical artery is a relatively common finding occurring in 0.2% of all births and of limited significance compared with the exceedingly rare finding of umbilical artery aneurysm.…”

“…A single umbilical artery is a relatively common finding occurring in 0.2% of all births and of limited significance compared with the exceedingly rare finding of umbilical artery aneurysm. 5,7,8 Three cases of cardiomegaly have been reported in fetuses with umbilical artery aneurysm. 5,6,8,9 There is no definitive evidence on the influence of a single umbilical artery on the development of an umbilical artery aneurysm.…”

“…However, single umbilical artery is the most commonly associated congenital anomaly in fetuses with umbilical artery aneurysm and normal karyotypes; in our review of the literature, it was present in 4 cases (67%) ( Table 2). 5,7,8 Given our limited understanding of this rare congenital anomaly, it is difficult to assess the role of umbilical artery aneurysm on development of cardiomegaly. It has been speculated that, in cases of a single umbilical artery, the artery may undergo a compensatory increase in size resulting in thinning of the arterial wall and aneurysm formation.…”

“…1,2,[4][5][6][7][8][9][10][11][12][13] Thrombosis and compression of neighboring vessels have been suggested as potential causes of IUFD in reported cases of umbilical artery aneurysm. 1,2,[4][5][6][7][8][9][10][11][12][13] Thrombosis and compression of neighboring vessels have been suggested as potential causes of IUFD in reported cases of umbilical artery aneurysm.…”