Umbelliprenin as a novel component of the phytochemical pool from Artemisia spp

Fiorito, Serena; Genovese, Salvatore; Palumbo, Lucia; Scotti, Luca; Ciulla, Michele; Profio, Pietro Di; Epifano, Francesco

doi:10.1016/j.jpba.2020.113205

Cited by 6 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Umbelliprenin (7-transfarnesyloxy coumarin) (UMB; C 2 H 30 O 3 ; molecular weight = 366), a member of the 7-prenyloxycoumarins, is a naturally occurring compound belonging to the sesquiterpene class and isolated from Ferula species, including Ferula szowitsiana [42,43]. Recently, it was also isolated from Artemisia absinthium for the first time [44].…”

Section: Chemistry Of Umbellipreninmentioning

confidence: 99%

“…UMB can exhibit cytotoxic effects against tumor cells with the ability to cause an inhibition in metastasis of tumor cells. UMB can affect multiple signaling cascades within the cells, i.e., intrinsic and extrinsic apoptotic pathways, Wnt and NF-ĸB activation, causes cell cycle arrest, as well as can modulate different inflammatory and immune related pathways ( Figure 2) [43][44][45][46][47][48][49][50][51][52][53][54]. UMB plays a potential therapeutic role affecting different growth regulatory pathways as summarized in Table 1 and Table 2.…”

Section: Role Of Umbelliprenin (Umb) In Cancer and Its Molecular Targetsmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin

et al. 2020

View full text Add to dashboard Cite

Cancer is one of the greatest causes of mortality worldwide. The prevalence rates of different types of cancer is increasing around the world as well. Limitations in chemotherapy and radiotherapy, owing to multiple side effects including cytotoxic effects of antitumor compounds on normal cells as well as the development of resistance to these treatment options in patients, create a serious threat to successful treatment of cancer. The use of natural compounds to prevent and treat cancers has been found to be quite effective, with fewer adverse effects found in patients. Umbelliprenin (UMB) is a naturally occurring sesquiterpene compound found in Ferula species and recently in Artemisia absinthium. Many studies have highlighted the antitumor potential of UMB in different cancer cell lines as well as in animal models. UMB exerts its anticancer actions by regulating extrinsic and intrinsic apoptotic pathways; causing inhibition of the cell cycle at the G0/G1 phase; and attenuating migration and invasion by modulating the Wnt signaling, NF-ĸB, TGFβ, and Fox3 signaling pathways. UMB also affects the key hallmarks of tumor cells by attenuating tumor growth, angiogenesis, and metastasis. This review provides an insight into the role of UMB as a potential antitumor drug for different malignancies and highlights the signaling cascades affected by UMB treatment in diverse tumor cell lines and preclinical models.

show abstract

Section: Chemistry Of Umbellipreninmentioning

confidence: 99%

Section: Role Of Umbelliprenin (Umb) In Cancer and Its Molecular Targetsmentioning

confidence: 99%

Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Solanaceae), Chenopodium quinoa Willd (Fam. Amaranthaceae) ( (Fiorito et al 2019c), and Artemisia vulgaris L. (Fiorito et al 2020). All these analytical studies were carried out by conventional techniques, namely HPLC and UHPLC, and part of which were the same used for auraptene.…”

Section: Umbellipreninmentioning

confidence: 99%

Auraptene and umbelliprenin: a review on their latest literature acquisitions

et al. 2020

Self Cite

View full text Add to dashboard Cite

Auraptene and umbelliprenin are among the most abundant naturally occurring prenyloxy umbelliferone derivatives. Both have been mainly isolated from plants belonging to numerous genera of the Rutaceae (in particular auraptene in Citrus spp.) and Apiaceae (in particular umbelliprenin in Ferula spp.) families, comprising different and widely used medicinal plants and in general plants having beneficial effects to human welfare as well as edible fruits and vegetables. Although known for quite a long time (nearly a century for auraptene and 50 years for umbelliprenin), only in the last two decades the two title natural compounds were revealed to possess valuable and promising pharmacological properties as dietary feeding active cancer chemopreventive, antibacterial, anti-protozoal, anti-fungal, anti-inflammatory, neuroprotective, and anti-oxidant agents among the activities best detailed in the recent literature. The aim of this comprehensive review is to outline in detail the effects described in the very last years for auraptene and umbelliprenin and what has been reported about the mechanisms of action underlying the observed pharmacological activities of these oxyprenylated secondary metabolites. In view of the herein described data suggestions on how to address the future research about both natural products in the best ways according to Authors will be also provided.

show abstract

“…The most recent articles in the literature concern the application of a novel extraction procedure based on the use of subcritical butane. Although this method was applied to already known sources of 7-isopentenyloxycoumarin like Citrus paradisi L. (Rutaceae) [21] and Artemisia vulgaris (Asteraceae) [22], both reports illustrate the great potential for the future of subcritical butane as an extraction solvent. In the case of grapefruit seeds, quantities determined for 7-isopentenyloxycoumarin (234.00 µg/g of dry extract) were higher than those obtained by any other extraction methodologies employed so far.…”

Section: New Natural Sourcesmentioning

confidence: 99%

7-Isopentenyloxycoumarin: What Is New across the Last Decade

et al. 2020

Self Cite

View full text Add to dashboard Cite

7-Isopentenyloxycoumarin is among the most widespread naturally occurring prenyloxy umbelliferone derivatives. This secondary metabolite of mixed biosynthetic origin has been typically isolated from plants belonging to several genera of the Rutaceae and Apiaceae families, comprising widely used medicinal plants and in general plants with beneficial effects on human welfare, as well as edible fruits and vegetables. Although known for quite a long time (more than 50 years), only in the last two decades has this natural compound been revealed to exert powerful and promising pharmacological properties, such as active cancer chemopreventive, antibacterial, antiprotozoal, antifungal, anti-inflammatory, neuroprotective, and antioxidant properties, among the activities best outlined in the recent literature. The aim of this comprehensive miniature review article is to detail the novel natural sources and the effects described during the last decade for 7-isopentenyloxycoumarin and what has been reported on the mechanisms of action underlying the observed biological activities of this oxyprenylated secondary metabolite. In view of the herein described data, suggestions on how to address future research on the abovementioned natural product and structurally related derivatives in the best ways according to the authors will be also provided.

show abstract

Umbelliprenin as a novel component of the phytochemical pool from Artemisia spp

Cited by 6 publications

References 26 publications

Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin

Assessment of the Antitumor Potential of Umbelliprenin, a Naturally Occurring Sesquiterpene Coumarin

Auraptene and umbelliprenin: a review on their latest literature acquisitions

7-Isopentenyloxycoumarin: What Is New across the Last Decade

Contact Info

Product

Resources

About