Umbelliferone Improves an Impaired Glucose and Lipid Metabolism in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Rats

Naowaboot, Jarinyaporn; Somparn, Nuntiya; Saentaweesuk, Suphaket; Pannangpetch, Patchareewan

doi:10.1002/ptr.5392

Cited by 34 publications

(13 citation statements)

References 31 publications

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“…The results of liver pathological section by haematoxylin and eosin staining showed reduced fat accumulation in the liver. Furthermore, expression of peroxisome proliferator‐activated receptor γ (PPARγ) and surface GLUT4 in adipose tissue was upregulated, suggesting that umbelliferone could enhance insulin sensitivity and promote GLUT4 translocation through activation of PPARγ. In type 1 diabetes, oxidative stress is an important factor which worsens pancreatic β‐cell dysfunction .…”

Section: Effects and Mechanisms Of Coumarins On Diabetesmentioning

confidence: 99%

Coumarins as potential antidiabetic agents

Yao

2017

Journal of Pharmacy and Pharmacology

150

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Objectives Even with great advances in modern medicine and therapeutic agent development, the search for effective antidiabetic drugs remains challenging. Coumarins are secondary metabolites found widely in nature plants and used mainly in anticoagulation and antithrombotic therapy. Over the past two decades, however, there has been an increasing body of literatures related to the effects of coumarins and their derivatives on diabetes and its complications. This review aimed to focus on research findings concerning the effects of coumarins against diabetes and its complications using in-vitro and in-vivo animal models, and also to discuss cellular and molecular mechanisms underlying these effects. Key findings The search for new coumarins against diabetes and it complications, either isolated from traditional medicine or chemically synthesized, has been constantly expanding. The cellular and molecular mechanisms involved include protecting pancreatic beta cells from damage, improving abnormal insulin signalling, reducing oxidative stress/inflammation, activating AMP-activated protein kinase (AMPK), inhibiting a-glucosidases and ameliorating diabetic complications. Conclusions The effects and mechanisms of coumarins and their derivatives upon diabetes and its complications are discussed in current review. Further investigations remain to be carried out to develop a promising antidiabetic agent based on coumarin cores.

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Section: Effects and Mechanisms Of Coumarins On Diabetesmentioning

confidence: 99%

Coumarins as potential antidiabetic agents

Yao

2017

Journal of Pharmacy and Pharmacology

150

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“…In Africa and Asia, S. alata leaves and flowers are currently used to regulate lipid absorption, obesity, and fat levels in blood serum. Aqueous leaf extract considerably reduced blood glucose levels, serum cholesterol, triglyceride, hepatic triglyceride, serum leptin, and insulin levels in Wistar mice [57].…”

Section: Antilipogenic Antidiabetic and Antihyperlipidemicmentioning

confidence: 89%

Ethnobotanical Description and Biological Activities of Senna alata

Oladeji

Adelowo

Oluyori

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Senna alata is a medicinal herb of Leguminosae family. It is distributed in the tropical and humid regions. e plant is traditionally used in the treatment of typhoid, diabetes, malaria, asthma, ringworms, tinea infections, scabies, blotch, herpes, and eczema. e review is aimed at unveiling the ethnobotanical description and pharmacological activities of S. alata. Different parts of the plant are reported in folk medicine as therapeutic substances for remediation of diverse diseases and infections. e extracts and isolated compounds displayed pronounced pharmacological activities. Display of antibacterial, antioxidant, antifungal, dermatophytic, anticancer, hepatoprotective, antilipogenic, anticonvulsant, antidiabetic, antihyperlipidemic, antimalarial, anthelmintic, and antiviral activities could be due to the array of secondary metabolites such as tannins, , and volatile oils present in different parts of the plant. e review divulges the ethnobotanical and pharmacological activities of the plant and also justifies the ethnomedical claims. e significant medicinal value of this plant necessitates a scientific adventure into the bioactive metabolites which constitute various extracts.

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“…Peroxisome proliferator-activated receptor γ (PPAR γ ) is an essential nuclear hormone receptor acting on the transcription of genes (e.g., glucose transporter gene GLUT4) involved in glucose disposal. A study finding reveals that umbelliferone upregulated the expression of surface GLUT4 gene and PPAR γ in adipose tissue, enhancing insulin sensitivity leading to increased peripheral glucose uptake [ 55 ]. Osthole also activated PPAR γ , increasing insulin sensitivity, and facilitated the synthesis and storage of fat [ 56 ].…”

Section: Beneficial Pharmacological Activities Of M Koenigii M Minutum and C Indica mentioning

confidence: 99%

Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review

Abeysinghe

Alwis

Kumara

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Murraya koenigii (M. koenigii), Micromelum minutum (M. minutum), and Clausena indica (C. indica) are three varieties of curry leaves in the family Rutaceae. They have been widely used in Ayurvedic medicine worldwide in the treatment and prevention of various diseases. Earlier findings provide strong evidence to support the three curry leaf species’ potent pharmaceutical and biological effects, including antioxidant, antidiabetic, anti-inflammatory, and antitumor activities. Various parts of these plants, such as leaves, seeds, flowers, and fruit, contain constituents responsible for the modulation of numerous biological processes. Leading constituents of curry leaves play a crucial role in diabetic and anticancer management by regulating various molecular pathways, including Bcl-2, Bax, NF-κB, and TNFα, according to in vitro and in vivo models established. Therefore, this review summarizes the current knowledge on research achievements made in terms of phytoconstituents, their structures, biological activities, and pharmacological actions with clinical studies of curry leaves up to date. The review also emphasizes the necessity for comprehensive research studies on the pharmacological actions and the mechanisms of selected phytochemicals of M. koenigii, M. minutum, and C. indica to validate their efficacy as potent herbal remedies for many ailments.

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Umbelliferone Improves an Impaired Glucose and Lipid Metabolism in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Rats

Cited by 34 publications

References 31 publications

Coumarins as potential antidiabetic agents

Coumarins as potential antidiabetic agents

Ethnobotanical Description and Biological Activities of Senna alata

Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review

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