Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats

Abdel-Wahab, Basel A.; Alkahtani, Saad A.; Alqahtani, Abdulsalam A.; Hassanein, Emad H.M.

doi:10.1007/s11356-021-18252-1

Cited by 17 publications

(8 citation statements)

References 82 publications

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“…Moreover, activation of the NLRP3 inflammasome enhances pyroptosis, an inflammatory form of cell death in the colonic mucosa [ 12 ]. This, in addition to the inhibitory effect of TLR4 on SIRT1 levels and its proven role in ROS production, supports the hypothesis that TLR4/NF-κB/NLRP3 inflammasome signaling is the keystone in the inflammatory events encountered in DSS-induced colitis [ 13 ].…”

Section: Discussionsupporting

confidence: 76%

“…Recent reports suggested that NLRP3 inflammasome augments colitis via affection of pyroptosis, a new type of proinflammatory programmed cell death, which has many differences from apoptosis and necrosis [ 12 ]. Moreover, activation of TLR-4 signaling is associated with increased production of reactive oxygen species (ROS) that elicits a series of secondary changes that ameliorate the antioxidant effects of sirtuin-1 (SIRT-1) in the colonic tissues [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

et al. 2022

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Colitis is one of the inflammatory states that affect the intestinal wall and may even predispose to malignancy due to chronic irritation. Although the etiology of colitis is not yet fully explored, a combination of genetic and environmental factors is strongly incriminated. Perindopril is an angiotensin-converting enzyme inhibitor that is used for the management of a wide range of cardiovascular diseases. Ambrosin is a sesquiterpene lactone that was proven to have beneficial effects in disorders characterized by inflammatory nature. The objective of this study is to make a comparison between the effects of perindopril or ambrosin on dextran sulfate sodium (DSS)-induced colitis in mice and to explore the effect of their combination. The present findings indicate that each ambrosin or perindopril alone or in combination is able to ameliorate oxidative stress and suppress the proinflammatory pathways in the colonic tissues of DSS-treated mice via mechanisms related to toll-like receptor 4/nuclear factor kappa B signaling and modulation of peroxisome proliferator-activated receptor gamma/sirtuin-1 levels. In addition, each ambrosin or perindopril alone or in combination inhibits apoptosis and augments the mediators of autophagy in DSS-treated mice. These effects are reflected in the amelioration of the histopathological and electron microscopic changes in the colonic tissues. Interestingly, the most remarkable effects are those encountered with the perindopril/ambrosin combination compared to the groups treated with each of these agents alone. In conclusion, the perindopril/ambrosin combination might represent an effective modality for mitigation of the pathogenic events and the clinical sequelae of colitis.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

et al. 2022

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“…53 Umbelliferone is a potential anti-inflammatory and antioxidant coumarin derivative. 54 Moreover, umbelliferone might be suitable for therapeutic application in colitis because it could alleviate the symptoms through the regulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways. 54 Noscapine is a plant-derived non-toxic alkaloid with anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

“…54 Moreover, umbelliferone might be suitable for therapeutic application in colitis because it could alleviate the symptoms through the regulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways. 54 Noscapine is a plant-derived non-toxic alkaloid with anti-inflammatory properties. 55 In summary, the increased levels of the above metabolites in the mEVs group might contribute to exerting anti-inflammatory function.…”

Section: Discussionmentioning

confidence: 99%

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

Quan

Zhao

et al. 2023

Food Funct.

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“…Umbelliferone not only significantly ameliorated histological damage in rats, but also treated UC by exerting anti-inflammatory and antioxidant effects. Its potential mechanism is to promote the SIRT1/PPARγ signaling pathway to protect UC rats [ 250 ].…”

Section: Nps With Ibd Therapeutic Activitymentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.

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Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats

Cited by 17 publications

References 82 publications

Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

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