Ulvan lyase assisted structural characterization of ulvan from Ulva pertusa and its antiviral activity against vesicular stomatitis virus

Chi, Yongzhou; Zhang, Meifang; Wang, Xin; Fu, Xinping; Guan, Huashi; Wang, Peng

doi:10.1016/j.ijbiomac.2020.04.187

Cited by 56 publications

(35 citation statements)

References 41 publications

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“…The average molecular weight of ulvan was 1068.2 kDa according to a previous research by Chi et al (2020) [ 20 ]. Because of its high molecular weight, ulvan usually shows poor biological absorption compared to oligosaccharide [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…The LMW-ulvan generated in this study was mainly composed of 57.23% Rha, 28.76% Xyl, 7.42% GlcA, and 1.77% Glc ( Figure 2 ). The monosaccharide composition of LMW-ulvan was slightly different from that of ulvan, whose molar percentage of Rha, Xyl, GlcA, IdoA, and Glc was 56.50%, 20.34%, 16.95%, 2.82%, and 3.39%, respectively [ 20 ]. The lyase used in this study belonged to the PL25 family, which cleaves the (1→4) glycosidic bond between 3- O -sulfated Rha and GlcA [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

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Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Han

Wang

et al. 2020

Marine Drugs

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Han

Wang

et al. 2020

Marine Drugs

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“…Antiviral capacities are widespread among many Ulvans from diverse Ulva species (e.g., U. compressa [73], U. lactuca [74], U. clathrata [75], U. intestinalis [76], U. armoricana [77] or U. pertusa [78]). These ulvans show antiviral activity against a panoply of enveloped viruses, notably HsV [73,77], Newcastle disease virus (NDV) [75], Japanese encephalitis virus (JEV) [74], Dengue virus [79], Influenza (H1N1) [29], Avian influenza virus [78], Vesicular stomatitis virus [80] and Measles virus [76].…”

Section: Ulvansmentioning

confidence: 99%

Antiviral Potential of Algal Metabolites—A Comprehensive Review

et al. 2021

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Historically, algae have stimulated significant economic interest particularly as a source of fertilizers, feeds, foods and pharmaceutical precursors. However, there is increasing interest in exploiting algal diversity for their antiviral potential. Here, we present an overview of 50-years of scientific and technological developments in the field of algae antivirals. After bibliometric analysis of 999 scientific references, a survey of 16 clinical trials and analysis of 84 patents, it was possible to identify the dominant algae, molecules and viruses that have been shaping and driving this promising field of research. A description of the most promising discoveries is presented according to molecule class. We observed a diverse range of algae and respective molecules displaying significant antiviral effects against an equally diverse range of viruses. Some natural algae molecules, like carrageenan, cyanovirin or griffithsin, are now considered prime reference molecules for their outstanding antiviral capacity. Crucially, while many algae antiviral applications have already reached successful commercialization, the large spectrum of algae antiviral capacities already identified suggests a strong potential for future expansion of this field.

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“…Ulva sp. as a nutraceutical agent can be utilized as food that shows beneficial physiological functions, improves well-being, and reduces the possibility of suffering from certain diseases, such as, inflammatory disorders [12], cancer [13], antibacterial [14], and virus infections [15,16]; and also act as an immunomodulating [17] and hypolipidemic agent [2,18]. It is widely believed that these functions are preventive rather than curative.…”

Section: Traditional Uses Of Ulvan From Ulva Spmentioning

confidence: 99%

“…In the isolation of the ulvan from the U. pertusa, the separation was carried out using a column chromatography equipped with a QFF column. The polysaccharides were eluted with a linear gradient of 0-2 M NaCl at 2.0 mL/min [16]. There is also isolation using ion column chromatography followed by a depolymerization process on the U. claratha [47].…”

Section: Isolation Purification and Characterizationmentioning

confidence: 99%

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

et al. 2020

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The species of green macroalga belonging to the genus Ulva (family: Ulvaceae) are utilized in various fields, from food supplements to biomedical applications. Ulvan, a polysaccharide obtained from various Ulva species, has shown various biological activities, including antioxidant, anti-inflammatory, anticancer, antibacterial, and antiviral activities. To obtain the polysaccharide ulvan that can be utilized in various fields, it is necessary to understand the critical points that affect its physicochemical nature, the extraction procedures, and the mechanism of action for biological activities. This article discusses the physicochemical properties, extraction, isolation and characterization procedures and benefits in food and biomedical applications of ulvan. In conclusion, ulvan from Ulva sp. has the potential to be used as a therapeutic agent and also as an additional ingredient in the development of tissue engineering procedures.

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Ulvan lyase assisted structural characterization of ulvan from Ulva pertusa and its antiviral activity against vesicular stomatitis virus

Cited by 56 publications

References 41 publications

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Antiviral Potential of Algal Metabolites—A Comprehensive Review

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

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