Ulvan loaded graphene oxide nanoparticle fabricated with chitosan and d-mannose for targeted anticancer drug delivery

Kesavan, Sonia; Meena, K.S.; Sharmili, S. Aruna; Govindarajan, Marimuthu; Alharbi, Naiyf S.; Kadaikunnan, Shine; Khaled, Jamal M.; Alobaidi, Ahmed S.; Alanzi, Khalid F.; Vaseeharan, Baskaralingam

doi:10.1016/j.jddst.2021.102760

Cited by 32 publications

(17 citation statements)

References 32 publications

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“…Nanomedicines are favorable to intravenous injection for the efficient delivery of drugs without any toxicity to normal cells [ 47 ]. In addition, the enzyme LO is known to cause the toxicity of L-lysine in blood plasma [ 3 ].…”

Section: Resultsmentioning

confidence: 99%

Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

et al. 2022

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Herein, we designed a nanocarrier to deliver the LO specifically to HER2+ breast cancer (BC) cells, where functionalization of mAb (anti-HER2+) with PEGylated chitosan enabled it to target the HER2+ BC cells. Taking advantage of overexpression of HER2+ in cancer cells, our nanocarrier (CS-LO-PEG-HER NPs) exhibited promising potency and selectivity against HER2+ BC cells (BT474). The CS-LO-PEG-HER NPs demonstrated the cytotoxicity in BT474 cells by promoting reactive oxygen species, mitochondrial membrane potential loss, and nucleus damage. The biocompatibility of CS-LO-PEG-HER NPs was evidenced by the hemolysis assay and H & E staining of major organs. The CS-LO-PEG-HER NPs showed anticancer potency against the BT474-xenograft tumor-bearing mice, as evident by the reduction of tumor size and cell density. These results indicate that CS-LO-PEG-HER NPs are biocompatible with mice while inhibiting tumor growth through alter the oxidative stress. Overall, this work provides a promising approach for the delivery of LO for good therapeutic effect in combination with mAb.

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Section: Resultsmentioning

confidence: 99%

Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

et al. 2022

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“…[ 124 ] The preparation of ulvan‐loaded graphene oxide nanocarriers fabricated with d ‐mannose and chitosan for the targeted release of anticancer drug have been represented in Figure . [ 131 ]…”

Section: Nanomedicines and Drug Delivery Systemmentioning

confidence: 99%

Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

et al. 2022

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A huge variety of polysaccharides can be obtained from algal biomass having several attractive properties such as cost‐effectiveness, non‐toxicity, biodegradability, abundant availability, and biocompatibility. In recent years, algal polysaccharides (including alginates, carrageenans, fucoidans, ulvans, and agaroses) have extensively been reported for their chemical properties and important bioactive potentialities. Furthermore, algal polysaccharides have gained huge scientific interest as they are a significant source of biologically active compounds, and they show various medical potentialities including anticancer, antiproliferative, anticoagulant, antitumoral, and antiviral properties. Exceptional physicochemical and biological characteristics make them interesting candidates for biotechnological and biomedical investigations. In this review, nanodrug delivery systems based on different algal‐polysaccharides (alginates, carrageenans, fucoidan, ulvan, and other) are described in a systematic way. Moreover, the current challenges and future prospects in the area of algal exploitation for biomedical applications are summarized at the end.

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“…Mannose-decorated CS-functionalized GO nanocarrier, loaded with sulfated polysaccharide ulvan from green macroalgae as a model anticancer drug, achieved drug entrapment efficiency of 88% and showed a pH-dependent-controlled drug release and targeted drug delivery in human glioblastoma cell line (U87) in vitro [ 131 ]. PEG functionalized GO nanocarrier is characterized with high delivery efficiency and controlled release of chemotherapeutics, anticancer drugs, and bioimaging agents as well as with high near-infrared (NIR) absorbance and capacity in photothermal treatment.…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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Ulvan loaded graphene oxide nanoparticle fabricated with chitosan and d-mannose for targeted anticancer drug delivery

Cited by 32 publications

References 32 publications

Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

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