The ‘Republic of Cyprus’, which today consists only of Greek Cypriots, has been carrying out activities to limit its marine zones in the Eastern Mediterranean, in order to explore natural resources. Turkey and Turkish Cypriots have been claiming that they also have legal rights over the maritime natural resources in Eastern Mediterranean. Another incident in the Eastern Mediterranean is the 2019 Memorandum of Understanding between Turkey and the UN-recognized government of Libya, namely the Government of National Accord, for delimiting their maritime zones. This is an important treaty for Eastern Mediterranean that effected the regional relations. This treaty is registered to the list of the UN Secretary General, and it must be respected by other actors. But the claims of other regional States such as the ‘Republic of Cyprus’ and the plans for EastMed pipeline conflicts with this treaty. Additionally, to these, two other important regional States, Israel and Lebanon, have been experiencing tensions due to their claims on maritime zones. This is another example of the unstable relations between the Eastern Mediterranean States. Parties of the Eastern Mediterranean disputes must coordinate a multilateral conference for solving all these disputes over Eastern Mediterranean delimitation activities and exploration of natural resources.