Ultraviolet–vis degradation of iprodione and estimation of the acute toxicity of its photodegradation products

Lassalle, Yannick; Jellouli, Héla; Ballerini, Laurie; Souissi, Yasmine; Nicol, Édith; Bourcier, Sophie; Bouchonnet, Stéphane

doi:10.1016/j.chroma.2014.10.051

Cited by 22 publications

(12 citation statements)

References 24 publications

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“…Media containing fully formed mycelium cells were supplemented with iprodione (Pestanal, Sigma-Aldrich) to a final concentration of 20 μM, the temperature was increased to 37 • C to induce the M→Y transition, and the transition was monitored in iprodionesupplemented and non-supplemented cultures by bright field microscopy at 5, 10, 24, 48, 72 and 96 h. Because iprodione is insoluble in water, dimethyl sulphoxide (DMSO) was used to solubilise the drug. Because the drug undergoes photodegradation in solution (Lassalle et al 2014), it was always freshly prepared and stored in the dark.…”

Section: Histidine Kinase Inhibition Assaymentioning

confidence: 99%

A conserved dimorphism-regulating histidine kinase controls the dimorphic switching inParacoccidioides brasiliensis

Chaves

Navarro

Castilho

et al. 2016

FEMS Yeast Research

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Paracoccidioides brasiliensis and P. lutzii, thermally dimorphic fungi, are the causative agents of paracoccidioidomycosis (PCM). Paracoccidioides infection occurs when conidia or mycelium fragments are inhaled by the host, which causes the Paracoccidioides cells to transition to the yeast form. The development of disease requires conidia inside the host alveoli to differentiate into yeast cells in a temperature-dependent manner. We describe the presence of a two-component signal transduction system in P. brasiliensis, which we investigated by expression analysis of a hypothetical protein gene (PADG_07579) that showed high similarity with the dimorphism-regulating histidine kinase (DRK1) gene of Blastomyces dermatitidis and Histoplasma capsulatum This gene was sensitive to environmental redox changes, which was demonstrated by a dose-dependent decrease in transcript levels after peroxide stimulation and a subtler decrease in transcript levels after NO stimulation. Furthermore, the higher PbDRK1 levels after treatment with increasing NaCl concentrations suggest that this histidine kinase can play a role as osmosensing. In the mycelium-yeast (M→Y) transition, PbDRK1 mRNA expression increased 14-fold after 24 h incubation at 37°C, consistent with similar observations in other virulent fungi. These results demonstrate that the PbDRK1 gene is differentially expressed during the dimorphic M→Y transition. Finally, when P. brasiliensis mycelium cells were exposed to a histidine kinase inhibitor and incubated at 37°C, there was a delay in the dimorphic M→Y transition, suggesting that histidine kinases could be targets of interest for PCM therapy.

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Section: Histidine Kinase Inhibition Assaymentioning

confidence: 99%

A conserved dimorphism-regulating histidine kinase controls the dimorphic switching inParacoccidioides brasiliensis

Chaves

Navarro

Castilho

et al. 2016

FEMS Yeast Research

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“…The inverse relationship between the target molecule and Cl-indicates an easily loss of Cl ring substituents, suggesting the HO• attack into the carbon-chloride bond as one of the firsts steps during IPR degradation. The susceptibility of these bonds have been also reported during the photodecomposition of IPR leading to the substitution of the Cl atoms by OH groups (Lassalle et al 2014). …”

Section: Main Degradation Pathwaysmentioning

confidence: 92%

“…It is mainly used against Botrytis on ornamentals plants such as carnation, chrysanthemum, and rose. It is also used in agricultural crops such as potato, tomato, and onion (Lassalle et al 2014).…”

mentioning

confidence: 99%

Degradation of a Toxic Mixture of the Pesticides Carbofuran and Iprodione by UV/H2O2: Evaluation of Parameters and Implications of the Degradation Pathways on the Synergistic Effects

Lopez-Alvarez

Villegas-Guzmán

Peñuela

et al. 2016

Water Air Soil Pollut

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The degradation of two pesticides, carbofuran (CBF) and ioprodine (IPR), was studied by the photolytic decomposition of hydrogen peroxide (UV/H 2 O 2 ). The influence of two experimental parameters, H 2 O 2 concentration and initial pH, as well as their interactions, was investigated. Optimization was carried out where experimental parameters were determined for the treatment of each pesticide. Both pesticides were totally eliminated by UV/H 2 O 2 system under optimal conditions. However, significant differences were found: CBF degradation was influenced by both parameters and their interactions, while IPR degradation was not statistically affected by initial pH. Interestingly, analysis of degradation pathways showed a major influence of photolysis process and oxidation due to hydrogen peroxide for the CBF degradation, while the synergistic combination between both of them played the most relevant role during IPR degradation. A mixture of both pesticides was also submitted to UV/H 2 O 2 action in which a lower rate was observed for IPR elimination while CBF was not affected. A 90 % of chemical oxygen demand (COD) was removed and 75 % of mineralization was achieved after the treatment of the mixture. Almost 92 % of the toxicity was eliminated making this technique a promising process to treat toxic mixtures of these pesticides.

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“…Some of them remain present in detectable amounts in commercial products such as grape juice . As they are directly applied on fruits and leaves, fungicides are exposed to direct sunlight and may undergo phototransformation processes . Fenbuconazole is part of the triazole molecules class, introduced as pesticides in the 1970s, that includes molecules containing the 1,2,4‐triazole moiety such as myclobutanil, propiconazol and tebuconazol .…”

mentioning

confidence: 99%

“…[7] As they are directly applied on fruits and leaves, fungicides are exposed to direct sunlight and may undergo phototransformation processes. [8][9][10] Fenbuconazole is part of the triazole molecules class, introduced as pesticides in the 1970s, that includes molecules containing the 1,2,4-triazole moiety such as myclobutanil, propiconazol and tebuconazol. [11,12] Applications of fenbuconazole pre-and post-harvest allow to inhibit various fungal diseases on fruits, vegetables and grain crops.…”

mentioning

confidence: 99%

Isomerization of fenbuconazole under UV‐visible irradiation – chemical and toxicological approaches

Lassalle

Nicol

Genty

et al. 2015

Rapid Comm Mass Spectrometry

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Ultraviolet–vis degradation of iprodione and estimation of the acute toxicity of its photodegradation products

Cited by 22 publications

References 24 publications

A conserved dimorphism-regulating histidine kinase controls the dimorphic switching inParacoccidioides brasiliensis

A conserved dimorphism-regulating histidine kinase controls the dimorphic switching inParacoccidioides brasiliensis

Degradation of a Toxic Mixture of the Pesticides Carbofuran and Iprodione by UV/H2O2: Evaluation of Parameters and Implications of the Degradation Pathways on the Synergistic Effects

Isomerization of fenbuconazole under UV‐visible irradiation – chemical and toxicological approaches

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