Ultraviolet Spectrophotometric Method for Determination of Glipizide in Bulk and Tablet Dosage Formulation

Nipanikar, Madhuri; Shrikrishna, Baokar; Undare, Santosh; Patil, R. N.

doi:10.5958/0975-4377.2016.00010.0

Cited by 3 publications

(1 citation statement)

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“…Glipizide (1-cyclohexyl-3-[[4-[2-[[(5-methylpyrazine-2-yl) carbonyl] amino] ethyl] phenyl] sulphonyl] urea), 1 is a secondgenerationsulfonyl urea derivative that is widely used as oral antihyperglycemic drug for the treatment non-insulin dependent diabetes mellitus [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Uv Spectrophotometricmethod for Quantitative Estimation of Glipizidein Pharmaceutical Dosage Form

Suryawanshi¹,

Afaqueansari²,

Kalshetti³

2020

Int J Curr Pharm Sci

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Objective: The present work is aimed to develop a simple, rapid, selective and economical UV spectrophotometric method for quantitative determination of Glipizideinbulk and pharmaceutical dosage form. Methods: In this method Dimethyl Form amide (DMF) was used as solvent, the absorption maxima was found to be275 nm in DMF. The developed method was validated for linearity, accuracy, precision, ruggedness, robustness, LOD and LOQ in accordance with the requirements of ICH guideline. Results: The linearity was found to be 10-60 µg/ml having linear equation y=0.017x-0.006 with correlation coefficient of 0.997. The% recovery was found to be in the range of 98.7-100%. The % RSD for intra-day and inter-day precision was found to be 0.569923 and 0.40169 respectively. The limit of detection (LOD) and limit of quantification (LOQ) was found to be3.06 µg/ml and 9.27 µg/ml respectively. Conclusion: The developed method was validated as per ICH Q2(R1) guidelines. The novel method is applicable for the analysis of bulk drug in its pharmaceutical dosage form.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of Uv Spectrophotometricmethod for Quantitative Estimation of Glipizidein Pharmaceutical Dosage Form

Suryawanshi¹,

Afaqueansari²,

Kalshetti³

2020

Int J Curr Pharm Sci

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Spectrophotometric Determination of Metformin in Different Pharmaceutical Combinations With Glipizide or Sitagliptin in Presence of Toxic Impurities of Metformin

Abdallah

Magdy

Abdelaleem

et al. 2021

Journal of AOAC INTERNATIONAL

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Background The presented quadruple divisor spectrophotometric method was able to resolve and analyze a complex quintuple drug matrix with severe overlapped spectra without previous separation or extraction steps or need of complicated apparatus like chromatographic methods and had the advantage of being green as the solvent used was water. Method Simple, sensitive and precise quadruple devisor spectrophotometric method was developed for simultaneous determination of metformin, glipizide, and sitagliptin in presence of metformin potential impurities melamine and cyanoguanidine. The proposed method was applied for analysis of metformin, glipizide, and sitagliptin in pure form and pharmaceutical formulation (tablets). The developed method was validated and met the requirements for ICH guidelines with respect to linearity, accuracy, precision, specificity and robustness. Results A linear response was observed in the range of 2-27, 2-20, 1-20, 0.5-10, and 1-10 μg/mL for metformin, glipizide, sitagliptin, melamine and cyanoguanidine, respectively with a correlation coefficient of 0.9996 and 0.9998, 0.9997, 0.9997 and 0.9996 for metformin, glipizide, sitagliptin, melamine and cyanoguanidine, respectively. Conclusion The validated method was successfully applied for determination of the studied drugs in Janumet® and Engilor® tablets; moreover the results were statistically compared to those obtained by the reported RP-HPLC method and no significant difference was found between them; indicating the ability of proposed method to be used for routine quality control analysis of these drugs.

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Quantitative Estimation of Roxithromycin and Ambroxol in Bulk and Tablet Dosage Forms by RP-HPLC Method

Umadevi

Hoque

2023

RJST

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A Rapid and Precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Roxithromycin and Ambroxol, in its pure form as well as in tablet dosage form. Chromatography was carried out on Altima C18 (4.6 x 150mm, 5µm) column using a mixture of ACN, Methanol and Phosphate buffer pH4.6 (10:25:65 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 215nm. The retention time of the Roxithromycin and Ambroxol was 2.344, 3.286±0.02min respectively. The method produce linear responses in the concentration range of 10-50mg/ml of Roxithromycin and 2.5-12.5mg/ml of Ambroxol. The method precision for the determination of assay was below 2.0 %RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

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Ultraviolet Spectrophotometric Method for Determination of Glipizide in Bulk and Tablet Dosage Formulation

Cited by 3 publications

References 0 publications

Development and Validation of Uv Spectrophotometricmethod for Quantitative Estimation of Glipizidein Pharmaceutical Dosage Form

Development and Validation of Uv Spectrophotometricmethod for Quantitative Estimation of Glipizidein Pharmaceutical Dosage Form

Spectrophotometric Determination of Metformin in Different Pharmaceutical Combinations With Glipizide or Sitagliptin in Presence of Toxic Impurities of Metformin

Quantitative Estimation of Roxithromycin and Ambroxol in Bulk and Tablet Dosage Forms by RP-HPLC Method

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