Ultraviolet Spectra and Carcinogenic Activities of Some Fluorene and Biphenyl Derivatives

Polymerization by oxidative coupling: Discovery and commercialization of PPO� and Noryl� resins

“…15,16 With this catalyst system olefins at Alberta. [2][3][4] were oxidized to a,b-unsaturated ketones, 17 alcoIn September, 1952, I went to the University hols and aliphatic ethers were oxidized to the corof Illinois to work under the supervision of Prof.…”

Microsomal deacetylation of ring-hydroxylated 2-(acetylamino)fluorene isomers: Effect of ring position and molecular mechanics considerations

“…To confirm the relative rates of deacetylation toward 2-AAF and its ring-hydroxylated derivatives observed in the foregoing spectrophotometric assays, the deacetylation reactions of 2-AAF and ring-hydroxylated derivatives were again studied, this time by HPLC, at the wavelength 290 nm, the k max of the parent compound 2-AAF (29). At different times of the reaction, an aliquot was taken and the disappearance of the 2-AAF or the corresponding hydroxylated derivatives were followed.…”

Miscellaneous Chemical Carcinogens: Chemical Constitution and Carcinogenic Activity

“…2-Methyl-4-acetylaminodiphenyl (VIII) and 2'-methyl-4-acetylaminodiphenyl (IX) are inactive in rats of both sexes (Sandin, Melby, Hay, Jones, Miller and Miller, 1952).…”

“…It has been suggested that the greater carcinogenic activity of derivatives of fluorene versus diphenyl derivatives is associated with the -CH2-bridge which helps to maintain a coplanar arrangement of the benzene nuclei (Miller, Miller, Sandin and Brown, 1949;Sandin et al, 1952). In this connection attention has been called to the striking difference in the incidence and distribution of tumours produced by 2-acetylaminofluorene, and 4-acetylaminodiphenyl, and the lack of activity in 2-methyl-4-acetylaminodiphenyl and 2'-methyl-4-acetylaminodiphenyl (Table I).…”