Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk

Watson, Meg; Holman, Dawn M.; Maguire-Eisen, Maryellen

doi:10.1016/j.soncn.2016.05.005

Cited by 195 publications

(159 citation statements)

References 87 publications

(85 reference statements)

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“…Banská Bystrica and Košice regions are also very close each other together with the mortality from C43-C44 (Melanoma and other malignant neoplasms of skin). It is appreciated that there are higher concentration of ultraviolet radiation or solar exposure which influence melanoma skin cancer (26)(27)(28). For complex explanation of these causalities, medical analyses would have to be conducted in Slovak regions.…”

Section: Discussionmentioning

confidence: 99%

Similarity of Slovak regions in neoplastic mortality in the context of risk factors and access to health care

Gavurová¹,

Popesko²,

Grabara³

et al. 2017

Cent Eur J Public Health

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SUMMARYAim: Access to primary health care is highly connected to the prevention of cancer mortality, since the risk factors threatening health can be early identified. The aim of this paper is, firstly, to explore similarity within and between the regions of the Slovak Republic and cancer mortality patterns, and secondly, to reveal if similar regions are characterised by the similar access to health care or risk factors occurrence.Methods: Data on deaths by sex, type of cancer death and region from 1996 to 2014 is provided by the National Health Information Centre of Slovakia. The relationships between 8 regions and 16 cancer types are described by correspondence analysis for both sexes.Results: The most similar cancer mortality patterns among Slovak regions are between the Nitra and Trnava regions for both sexes, and the Košice region for males. The Prešov region is showed as an outlier from other regions for females, likely due to the highest concentration of Roma marginalised communities. As for access to health care, the Trnava region as well as Nitra region report the lowest densities of physicians, 2.4 and 2.6 per 1,000 inhabitants, respectively. The most serious cancer types mortality is attributed to the digestive organs (C15-C26) in each Slovak region for both sexes with the average proportion of 35.56%. Observed high association between the Nitra region and respiratory cancer (C30-C39) in males may be confirmed by the increased incidence of radon in this region. Similarly, a tight relationship between the Bratislava region and cancer of male genital organs (C60-C63) can relate to the highest proportion of drug users in the Bratislava region.Conclusions: Based on the findings of similar regions in cancer mortality patterns, we recommend to set the same prevention programs in the Trnava and Nitra regions, on the other hand, different preventive interventions should be introduced in the Prešov region.

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Section: Discussionmentioning

confidence: 99%

Similarity of Slovak regions in neoplastic mortality in the context of risk factors and access to health care

Gavurová¹,

Popesko²,

Grabara³

et al. 2017

Cent Eur J Public Health

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“…UVA exposure causes free radical production that leads to oxidative damage and DNA damage indirectly. UVB causes DNA damage leading to driver and bystander mutations as well as photo by‐products leading to cellular transformation and malignancy . Despite the harmful photocarcinogenic and immune suppressive effects of sunlight, UVB wavelengths of 290‐315 nm are also responsible for vitamin D synthesis to carry out its endocrine function.…”

Section: Skin Carcinogenesis and Vitamin Dmentioning

confidence: 99%

Exploring vitamin D signalling within skin cancer

Vishlaghi

Lisse

2020

Clinical Endocrinology

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Sunlight exposure of the skin is associated with both risks and benefits. On one hand, sunlight ultraviolet (UV) radiation can cause skin cancer through signature DNA mutations. On the other hand, it can be absorbed in the skin by 7‐dehydrocholesterol to instigate endogenous synthesis of vitamin D to regulate anticancer effects. Thus, protecting one's skin from sunlight to avoid skin cancer may lead to impaired vitamin D levels arguing for sensible sun exposure practices. To limit cancer, vitamin D metabolites can promote uncharacterized and diverse sets of events such as repair responses to DNA damage, apoptosis of malignant cells, and suppression of immune surveillance, proliferation and angiogenesis. Recent findings also suggest that part of the anticancer effects of vitamin D within squamous cell carcinoma—a type of skin cancer most directly linked to sun exposure—involves the DDIT4‐mTOR catabolic signalling pathway to enhance cell autophagy. As mTOR activity and cellular metabolism are modulated as part of the DNA damage response, insights into the means by which mTOR can be controlled by vitamin D to suppress cancer is of molecular and clinical importance. Overall, the research so far suggests that presence of vitamin D through sunlight exposure and supplementation are beneficial for human health in the face of cancer.

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“…Several reports suggest that systemic sclerosis (SSc), which mostly affects lungs, breasts, and the hematological system, is also associated with the increased risk of malignancy (Zeineddine et al, 2016). Exposure to ultraviolet (UV) radiation is another factor responsible for skin cancer as it stimulates skin cell damage, and intense exposures may even result in cell death (Watson et al, 2016). Moreover, recent reports revealed that oral environment is also associated with cancer as it functions as the bodily entrance for food and air and is exposed to various foreign substances including bacteria and viruses (Kudo et al, 2016).…”

Section: Other Factorsmentioning

confidence: 99%