Ultraviolet‐B treatment for cutaneous lichen planus: our experience with 50 patients

Pavlotsky, Felix; Nathansohn, Nir; Kriger, Grigory; Shpiro, Dorit; Trau, Henri

doi:10.1111/j.1600-0781.2008.00344.x

Cited by 52 publications

(37 citation statements)

References 14 publications

(21 reference statements)

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“…The disease can be generalised where systemic therapies were given in order to treat the disease. [2,3,4,5,6,7,8,9,10] Out of all systemic modalities oral corticosteroids, [3,11,12,13] are the mainstay of therapy, in present study an attempt was made to compare the efficacy between oral mini pulse therapy with betamethasone, [12] and oral acitretin. [5] Age Distribution: In present study, Out of 60 patients, 78.33% of lichen planus cases were in age group of 30-60years which is comparable to western study by melgren et al Sex distribution ( Table 9): In present study female patients outnumbered males in a ratio of 2.1:1, which is nearly comparable to study by vijay kumar et al, In a study done by ramesh et al, [13] male patients outnumbered females, (54.28%) patients were males and 16(45.71%) were females.…”

Section: Resultsmentioning

confidence: 99%

“…The present study was done to compare the efficacy between oral betamethasone mini pulse therapy and oral acitretin and to know the relapse rate. [2,3,4,5,6,7,8,9,10] MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen planus, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Visakhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

P¹,

S²,

Shalini³

et al. 2015

jemds

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BACKGROUND:Lichen planus is a chronic inflammatory disease that effects skin, mucous membranes, hair and nails. There are several drugs both topical and systemic for the treatment of lichen planus. AIMS AND OBJECTIVES: Present study was done to compare the efficacy between oral mini pulse therapy with betamethasone and with acetretin in the management of generalised lichen planus. MATERIALS AND METHODS: The study was carried out on patients who were clinically diagnosed as generalised lichen planus, attending the outpatient department of dermatology, venereology and leprosy, King George hospital, affiliated to Andhra medical college, Vishakhapatnam from November 2011 to December 2012. A total of 60 patients were included in study and divided into two equal groups. Group1 patients were treated with 0.1mg/kg of oral betamethasone given on 2 consecutive days in a week till 8 weeks and tapered. Group 2 patients were treated with 0.5mg/kg of acetretin for 8 weeks and tapered. INCLUSION CRITERIA: All patients of age group in between 11-60 years, of either sex, suffering from lichen planus of duration >3 months, and women in group 2 who were in reproductive age group on two methods of contraception were included. EXCLUSION CRITERIA: Pregnant and lactating women, in Group 1: patients suffering from diabetes, hypertension, peptic ulcer disease, renal, hepatic, heart disease or tuberculosis, in Group 2: patients with abnormal lipid profile, diabetes, hypertension, renal, liver or heart disease were excluded. RESULTS: out of 60 patients enrolled in study, 2 patients from group 1 and 5 patients from group 2 were dropped from study and results were concluded. Majority of patients were in age group of 31-60 (78.3%) with male to female ratio of 2.1:1.Group 1 patients at the end of 8 weeks response was seen in 92.8%, with relapse rate of 15.38% after 6 months of follow up. Group 2 patients at end of 8 weeks response was seen in 72 % with relapse rate of 5.5%. CONCLUSION: In our study oral mini pulse therapy with betamethasone has early onset of action and with a complete response in majority of patients with slightly more relapse rate when compared to oral acetretin. Oral acetretin has less relapse rate due to prolonged half-life.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

P¹,

S²,

Shalini³

et al. 2015

jemds

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“…[11] Complications Malignant transformation has been reported in ulcerative Oral Lichen Planus (OLP). [12] Cutaneous hypertrophic lichen planus resulting in Squamous Cell Carcinoma (SCC) was reported in a series of 38 patients. [13] Pruritic and painful vulvar lichen planus has been a precursor to SCC in a small number of cases.…”

Section: Medical Treatmentmentioning

confidence: 99%

A Clinical and Histopathological Study of Lichen Planus

Babu¹,

Padmaja²,

M³

2016

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“…Aus dieser Erfahrung heraus führten wir eine kleine Gruppe von Patienten mit generalisiertem Lichen ruber ebenfalls dieser Kombinationstherapie zu. Obwohl einige Studien über gute Resultate einer NUVB-Therapie bei Lichen ruber mit Remissionsraten von 50-70% berichteten [24,36], ist eine PUVA-Therapie -zumindest in der Anfangsphase [36] allen anderen Therapien überlegen.…”

Section: Diskussionunclassified

Targeted UVB-308 nm (NUVB) therapy with excimer laser in the treatment of atopic dermatitis and other inflammatory dermatoses

2009

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UVB 311 nm phototherapy (NUVB) is used successfully in the treatment of psoriasis or atopic dermatitis and is often chosen as "first-line" therapy. In a prospective study we investigated the efficacy of the targeted UVB 308 phototherapy by excimer laser in the treatment of 57 patients with localized, mild therapy-resistant atopic dermatitis. We achieved a complete remission (CR) in nearly 85% and a partial remission (PR) in 15% after 10 treatments during 6-8 weeks in all patients. A mean reduction in patient-reported pruritus was one hallmark after 3-4 treatments. 48 other patients with lichen simplex chronicus Vidal, nodular prurigo, granuloma anulare, alopezia areata (AA) and lichen ruber planus were also treated by targeted NUVB. We found higher rates of CR and PR only in patients with AA and in patients with oral Lichen ruber mucosae. These results and the systematically reviewing of the current medical literature shows that targeted NUVB by excimer laser cannot be successfully transferred for all inflammatory skin diseases. In particular, Excimer UVB treatment expands the therapeutic options in patients with localized and therapy-resistant atopic dermatitis enormously.

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Ultraviolet‐B treatment for cutaneous lichen planus: our experience with 50 patients

Abstract: UVB is a safe and efficient treatment option for generalized cutaneous lichen planus.

Cited by 52 publications

References 14 publications

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

A Study of Comparative Effeiciency of Oral Mini Pulse Therapy Versus Oral Acitret in in Genaralised Lichen Planus

A Clinical and Histopathological Study of Lichen Planus

Targeted UVB-308 nm (NUVB) therapy with excimer laser in the treatment of atopic dermatitis and other inflammatory dermatoses

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