Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity

Abstract

Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors that influence immune tolerance.

A Potential Beneficial Effect of Ultraviolet Phototherapy on Relapsing Remitting Multiple Sclerosis.

“…Moreover, a statistically significant improvement in the scores EDSS, IPSS and BARS were detected; on the other hand the scores of MAS did not change significantly. In agreement with our results, several studies have reported significant improvement in the EDSS of RRMS patients after either broad band UVB phototherapy as our study (Essa et al, 2016) or narrow band UVB phototherapy ( for 5times/week for 6 weeks) (Breuer et al,2014).…”

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells

“…PCR has been performed as described previously (Breuer et al, 2014). In short, RNA was extracted from primary human brain microvascular endothelial cells using TRIzol reagent (Invitrogen).…”

Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity

“…A retrospective data analysis conducted in France showed an association between regional variation in MS prevalence and UVB radiation (Orton et al, 2011). While UVB radiation is also thought to have a VD independent immunomodulatory effect (Breuer et al, 2014), it contributes to approximately 90% of the body's 25(OH) D supply (Federal Office for Radiation Protection (Germany), 2012).…”