Ultraviolet-A (UVA-1) radiation suppresses immunoglobulin production of activated B lymphocytes<i>in vitro</i>

Polderman, Marloes C. A.; Kooten, Cees van; Smit, Nico P.M.; Kamerling, Sylvia W.A.; Pavel, S.

doi:10.1111/j.1365-2249.2006.03136.x

Cited by 21 publications

(32 citation statements)

References 21 publications

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“…Increased apoptosis of skin‐infiltrating white blood cells has also been reported following UVA‐1 radiation . Furthermore, attenuated B‐cell immunoglobulin production and lower anti‐dsDNA titers were found with UVA‐1 exposure in vitro .…”

Section: Uva‐1 Therapy For Lupus Patientsmentioning

confidence: 88%

“…Increased apoptosis of skin-infiltrating white blood cells has also been reported following UVA-1 radiation (51). Furthermore, attenuated B-cell immunoglobulin production and lower anti-dsDNA titers were found with UVA-1 exposure in vitro (52). Despite these promising results, UVA-1 radiation in SLE patients is not a common therapeutic modality.…”

Section: Uva-1 Therapy For Lupus Patientsmentioning

confidence: 99%

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Photosensitivity in cutaneous lupus erythematosus

Kim

Chong

2013

Photoderm Photoimm Photomed

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Cutaneous lupus erythematosus (CLE) encompasses several different forms including acute, subacute, and chronic manifestations that may or may not occur in the setting of systemic lupus erythematosus (SLE). Ultraviolet radiation (UVR) is a well-known exacerbating factor for CLE, with photosensitivity comprising one of the American College of Rheumatology (ACR) diagnostic criteria for SLE. However, discerning true photosensitivity in this population is difficult due to the broad language utilized by the ACR and the delayed-onset nature of photosensitive lupus lesions. Photoprovocation testing provides a more objective method to measure photosensitivity, but photoprovocation trials demonstrate significantly varying results due to protocol variations. Despite UVR’s deleterious effect on lupus patients, UVA-1 may have therapeutic benefits as shown by some observations on murine and human lupus subjects. Accurately discerning photosensitivity has diagnostic implications for SLE and provides motivation for greater patient adherence to photoprotective measures.

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Section: Uva‐1 Therapy For Lupus Patientsmentioning

confidence: 88%

Section: Uva-1 Therapy For Lupus Patientsmentioning

confidence: 99%

Photosensitivity in cutaneous lupus erythematosus

Kim

Chong

2013

Photoderm Photoimm Photomed

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“…jor histocompatibility complex (MHC) with a vital role in the immune system (15). Another study has shown that UV radiation causes apoptosis of B lymphocytes, resulting decrease in immunoglobulins such as IgM, IgG, IgA, and IgE (16).…”

Section: Introductionmentioning

confidence: 99%

The Role of Curcumin on Reduced Leukocyte and Platelet Counts in Rats After Exposure to Ultraviolet Light from Compact Fluorescent Lamps: A Morphological Study

et al. 2019

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Background: Compact fluorescent lamps (CFLs) could be a source of ultraviolet (UV) radiation with potential harmful effects. Objectives: We assessed the effects of ultraviolet radiation on leukocyte and platelet counts in rats and also investigated the preservative effects of curcumin on hematologic disorders caused by UV radiation. Methods: We randomly divided 48 male Sprague-Dawley rats into six groups (n = 8). Two control groups received ethyl oleate (0.2 mL, IP) for 10 (group I) and 30 days (group II), without exposure to fluorescent light. Two fluorescent groups treated daily with 12 hours fluorescent light exposure for 10 (group III) and 30 days (group IV). Group V and VI received curcumin (20 µmol, IP) and 12 hours fluorescent light exposure for 10 and 30 days, respectively. The blood samples were collected and the leukocyte indexes were measured by cell counter and blood smears were obtained.Results: The number of leukocytes was significantly lower in groups III (8.36 ± 0.23 × 10 3 /µL) and IV (7.85 ± 0.18 × 10 3 /µL) compared with groups I (8.78 ± 0.14 × 10 3 /µL) and II (8.50 ± 0.20 × 10 3 /µL). (P value III:I = 0.004, IV:II < 0.0001). The number of leukocytes insignificantly increased to normal levels of 8.85 ± 0.29 × 10 3 /µL and 8.30 ± 0.16 × 10 3 /µL in groups V and VI, respectively (P value V:I = 0.79, VI:II = 0.09). The number of platelets (PLTs) was significantly lower in the groups IV and VI in comparison with the group II (750 ± 6.52 × 10 3 /µL, 808 ± 2.13 × 10 3 /µL and 846 ± 2.73 × 10 3 /µL, respectively (P value IV:II < 0.0001, VI:II < 0.0001). In the morphological pattern of leukocytes, the CFLs lead to atopic cells, bond cells, and cell lysis, however, administration of curcumin prevented this disturbance. Conclusions: Curcumin has a protective role in reducing complications caused by CFLs in reduced leukocyte and platelet counts, which is probably due to its antioxidant agent.

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“…UVA radiation without riboflavin induced lymphocyte apobiosis (20–21). Our preliminary data also showed that more than 70% of lymphocytes was inhibited following treatment with UVA radiation.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Lymphocytes in Blood Products Using Riboflavin Photochemical Treatment with Visible Light

Cui

Huang

Qin

et al. 2008

Photochem & Photobiology

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Immunocompetent lymphocytes present in blood products are an important cause of immune reactions following blood transfusion such as transfusion-associated graft-versus-host disease (TA-GVHD). In this study the effects of riboflavin photochemical treatment (RPT) on lymphocyte proliferation and cytokine production in vitro were measured to establish whether RPT of blood products can be used to prevent immune reactions resulting from transfused lymphocytes. Lymphocytes and riboflavin were added together in medical PVC transparent bags and then exposed to visible light. Control lymphocytes were exposed to light in the absence of riboflavin. Lymphocytes exposed to riboflavin photochemical treatment (RPT-lymphocytes) and control lymphocytes were tested for the proliferative ability and the production of several cytokines upon stimulation with antigens. Upon stimulation by phytohemagglutinin (PHA) the proliferation of RPT-lymphocytes was inhibited. Using flow cytometry it was shown that RPT-lymphocytes were unable to enter the S-phase of the cell cycle following PHA stimulation. The level of cytokines present in the supernatant of RPT-lymphocytes after stimulation by antigens was significantly lower than those present in the corresponding supernatant of control lymphocytes. RPT with visible light inactivates lymphocytes, inhibits lymphocyte proliferation and the production of cytokines. It appears to be a promising method to prevent immune reactions such as TA-GVHD.

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Ultraviolet-A (UVA-1) radiation suppresses immunoglobulin production of activated B lymphocytesin vitro

Cited by 21 publications

References 21 publications

Photosensitivity in cutaneous lupus erythematosus

Photosensitivity in cutaneous lupus erythematosus

The Role of Curcumin on Reduced Leukocyte and Platelet Counts in Rats After Exposure to Ultraviolet Light from Compact Fluorescent Lamps: A Morphological Study

Inactivation of Lymphocytes in Blood Products Using Riboflavin Photochemical Treatment with Visible Light

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