2006
DOI: 10.1111/j.1600-0781.2006.00229.x
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Ultraviolet A in vitiligo

Abstract: Both types of Ultraviolet (UV), UVB (290-320 nm) and UVA (320-400 nm), produce increased pigmentation or tanning. However, no evaluation of UVA alone in the treatment of vitiligo has been reported. Therefore, it was the purpose of this work to study the pigmentogenic effect of UVA (5 and 15 J/cm(2)) in vitiligo. The study included 20 randomly selected patients with vitiligo involving more than 30% of the body surface area with a bilateral/symmetrical distribution. They were equally divided into two groups each… Show more

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Cited by 25 publications
(19 citation statements)
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“…58 PUVA is approved by the FDA for the treatment of vitiligo, 59 but high doses of UVA alone (15 J/cm 2 ) induce repigmentation of more than 60% in half of subjects. 60 Enhanced with psoralen, response rates are as high as 78% and up to 100% for head and neck lesions in more than half of subjects. Lesions on the extremities are less responsive.…”
Section: Phototherapy Key Pointsmentioning
confidence: 98%
“…58 PUVA is approved by the FDA for the treatment of vitiligo, 59 but high doses of UVA alone (15 J/cm 2 ) induce repigmentation of more than 60% in half of subjects. 60 Enhanced with psoralen, response rates are as high as 78% and up to 100% for head and neck lesions in more than half of subjects. Lesions on the extremities are less responsive.…”
Section: Phototherapy Key Pointsmentioning
confidence: 98%
“…Long‐wave ultraviolet A1 (UVA1) (340‐400 nm) therapy with low dose [10‐30 Joules (J)/centimeter 2 (cm 2 )], medium dose (40‐70 J/cm 2 ), and high dose (up to 130 J/cm 2 ) has been used since 1981 . UVA1 can penetrate deeper than UVA2 (320‐340 nm) and therefore could reach deeper in the skin dermis . UVA1 has common biological effects with NB‐UVB with almost none of the adverse effects associated with other phototherapeutic modalities.…”
Section: Introductionmentioning
confidence: 99%
“…The use of BB-UVA alone without the addition of photosensitizers has been attempted in a pilot study [91] that included 20 randomly selected patients with bilateral symmetrical vitiligo involving more than 30% of the body surface area. They were equally divided into two groups and all patients received three weekly sessions of UVA, 15 J/cm 2 in group I and 5 J/cm 2 in group II.…”
Section: Psoralen and Solar Exposurementioning
confidence: 99%