Ultrathin Covalent Organic Framework Nanosheets/Ti3C2Tx-Based Photoelectrochemical Biosensor for Efficient Detection of Prostate-Specific Antigen

Abstract

Designable and ultrathin covalent organic framework nanosheets (CONs) with good photoelectric activity are promising candidates for the construction of photoelectrochemical (PEC) biosensors for the detection of low-abundance biological substrates. However, achieving highly sensitive PEC properties by using emerging covalent organic framework nanosheets (CONs) remains a great challenge due to the polymeric nature and poor photoelectric activity of CONs. Herein, we report for the first time the preparation of novel composites and their PEC sensing properties by electrostatic self-assembly of ultrathin CONs (called TTPA-CONs) with Ti3C2Tx. The prepared TTPA-CONs/Ti3C2Tx composites can be used as photocathodes for PEC detection of prostate-specific antigen (PSA) with high sensitivity, low detection limit, and good stability. This work not only expands the application of CONs but also opens new avenues for the development of efficient PEC sensing platforms.

Recent advances in photoelectrochemical platforms based on porous materials for environmental pollutant detection

“…Moreover, the electronic interactions between the COF layers are realized by the p-stacked aromatic subunits, providing sufficient channels for charge transport. [130][131][132] So far, several COFs have been employed in the eld of PEC detection, such as D-TA COF, 133,134 TAPP-COF, 124 TTPA-COF, 135 F-COF, 125 pbqy-COF, 136 and PFA-130. 137 However, the studies on PEC sensors based on covalent organic frameworks for tracing environmental pollutants are still in their early stages, as summarized in Table 6.…”

Chiral Covalent-Organic Framework MDI-β-CD-Modified COF@SiO2 Core–Shell Composite for HPLC Enantioseparation

“…These materials have the characteristic of low density, rich active sites, large specific surface areas, and good chemical stability. In the last few years, they have been broadly utilized in many fields, such as drug delivery [ 5 , 6 ], catalysis [ 7 ], gas adsorption and separation [ 8 , 9 ], electrochemical sensing [ 10 , 11 ] and chromatographic separation [ 12 , 13 ]. In particular, the usage of CCOFs as novel chiral stationary phases (CSPs) in chromatographic separation has attracted extensive attention [ 14 ].…”

Magnetic ε-Phosphorene for Sensing Greenhouse Gas Molecules

“…Two-dimensional (2D) materials demonstrate immense potential as chemical sensors [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ], in spintronics applications [ 13 , 14 , 15 , 16 , 17 , 18 ], and in other exotic applications [ 19 ] due to their vast surface-to-volume ratio, potent surface activity, and remarkable electrical conductivity. For instance, Muhmood et al enhanced the photoelectrocatalytic property of a g-C 3 N 4 (with a narrow bandgap)/GNP/AgBr heterojunction through collaborative efforts [ 20 ].…”