Abstract:The secretory cells of the mammary gland are very diverse in their size, shape, and structure. These are highly specialized cells adapted to the synthesis, accumulation, storage, and excretion of milk. The main feature of glandular cells is the presence of secreted substances. Electron microscopy shows that substances of different secretory cells types have various electron densities. Occasionally, two or more types of secretory granules differing in size and composition can be found in one cell. The material … Show more
“…The conventional biological cryomicrotome cannot cut slices with thickness less than a micron. In order to explore the effect of nanoscale slices on mass spectrometry imaging, a Leica ultrathin cryomicrotome 34 was used to obtain nanometer scale slices. Our work is the first study in which nanoscale slices were used for MALDI MSI.…”
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has become a powerful tool for studying the spatial distribution of molecules. Preparation of tissue sections is a critical step for obtaining...
“…The conventional biological cryomicrotome cannot cut slices with thickness less than a micron. In order to explore the effect of nanoscale slices on mass spectrometry imaging, a Leica ultrathin cryomicrotome 34 was used to obtain nanometer scale slices. Our work is the first study in which nanoscale slices were used for MALDI MSI.…”
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has become a powerful tool for studying the spatial distribution of molecules. Preparation of tissue sections is a critical step for obtaining...
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