Ultrastructure of the bovine temporomandibular joint disc

Kuc, Iris M.; Scott, Paul

doi:10.1016/0003-9969(94)90035-3

Cited by 26 publications

(13 citation statements)

References 19 publications

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“…Morphologically, collagen fibrils were oriented anteroposteriorly parallel to the surface of the disc in the intermediate zone, but were oriented circumferentially in the peripheral region [27]. Collagen fibrils in the peripheral region of the disc are thicker than those in the central region [16]. Compared to fibrils of type I collagen, type III collagen fibrils are thinner and distensible [21].…”

Section: Discussionmentioning

confidence: 98%

“…The TMJ disc contains a variety of ECM components, such as collagens, proteoglycans and related glycosaminoglycans [2,4,14,16,17,20,28]. Types II and IX collagen, which are characteristic components of cartilage, were found in bovine TMJ disc [17].…”

Section: Discussionmentioning

confidence: 99%

“…Collagens and proteoglycans (PG)s are prominent extracellular matrix (ECM) components in the TMJ [2,4,8,10,14,16,17,22,23,29,33]. Over 10 genetically and structurally distinct types of collagen have been found in various connective tissues, and these can be divided into two different subgroups, i.e., fibrillar and FACIT (fibril-associated collagen with interrupted triple helices) [15].…”

Section: Introductionmentioning

confidence: 99%

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An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Hamaya

Takahashi

Sasano

et al. 2001

Acta Histochem. Cytochem

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We sought to immunohistochemically localize types I, II and III collagen in various regions of the temporomandibular joint (TMJ) in two female rhesus monkeys at different growth stages: juvenile and late-adolescence. In the condylar cartilage, staining for types I and III collagen was weak in the fibrous layer, intense in the pre-cartilaginous layer, and faint in the cartilaginous layer, whereas that for type II collagen was limited to the cartilaginous layer. The glenoid fossa showed moderate staining for type I collagen and weak staining for type II collagen, indicating that this tissue consists of chondroid bone, which is an intermediary between bone and cartilage. TMJ discs showed more intense staining for types I and III collagen in their periphery than in their centers. Staining for type II collagen was not detected throughout the disc. The posterior attachments showed rather weak staining for type I collagen and relatively intense staining for type III collagen. These results suggest that there are regional differences in the phenotypic expression of the three major collagen components in the growing monkey TMJ, which probably provide specific biomechanical resistance.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Hamaya

Takahashi

Sasano

et al. 2001

Acta Histochem. Cytochem

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“…Histological and chemical analyses of the bovine TMJ discs showed the regional differences in ECM organization and composition; the peripheral region had (1) thinner and more loosely packed collagen fibrils, (2) less chondroitin sulphate, (3) more decorin, and (4) less content of biglycan, compared to those of the peripheral region (Nakano and Scott 1989;Kuc and Scott 1994;Scott et al 1995;Mizoguchi et al 1998). These regional differences are thought, at least in part, to reflect the biomechanical environment of the TMJ disc.…”

Section: Discussionmentioning

confidence: 98%

Expression and localization of versican during postnatal development of rat temporomandibular joint disc

Toriya

Teratani

Arakawa

et al. 2005

Histochem Cell Biol

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To analyze the growth-related changes in extracellular matrix components in temporomandibular joint (TMJ) discs, the expression and localization of the core protein of a large chondroitin sulphate proteoglycan, versican, in rat TMJ discs during postnatal development (2-32 weeks) were examined using Western blot analysis, real-time quantitative PCR and immunohistochemistry. Western blot analysis showed that rat TMJ discs predominantly expressed one isoform (V1) and the core protein sharply increased after birth, reached a peak at 8 weeks, and then gradually decreased up to 32 weeks. Real-time quantitative PCR with TaqMan probes indicated that mRNA expression of versican was highest at 2 weeks and gradually decreased with growth. An immunohistochemical study showed that staining for versican was weak and evenly distributed in TMJ discs at 2 weeks. Regional differences in staining for versican became prominent after 8 weeks; staining was intense in the anterior and posterior peripheral attachments, and weak in the central part of the discs. These results demonstrate that growth-related changes and regional differences exist in the expression of versican in the TMJ discs of growing rats, and these probably reflect the changes in the biomechanical environment caused by the development of orofacial functions.

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“…41 The present data showed considerable reductions in stress magnitude in the anterior, central, and medial regions of the mandibular condyle as a result of the use of poly-L/DL-lactide implant to replace the articular disc, and led us to support the newly made hypothesis that the mandibular condyle more likely functions as a shock absorber than the disc. 38 The biologic basis for potentially a better shock-absorbing role of the mandibular condyle than the disc is that the disc in several species consists of largely fibrous tissue, 42,43 whereas the condylar fibrocartilage is composed of mostly large proteoglycans such as aggrecan and versican. 44,45 In general, large proteoglycans such as aggrecan and versican are more suited for resisting compressive forces (shockabsorbing) than the fibrous articular disc that is known to be composed of mostly collagen fibers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tissue-Engineered Articular Disc Implants on the Biomechanical Loading of the Human Temporomandibular Joint in a Three-Dimensional Finite Element Model

Al-Sukhun¹,

Ashammakhi²,

Penttilä³

2007

Journal of Craniofacial Surgery

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The purpose of this study was to evaluate biomechanical loading of the temporomandibular joint when using a biodegradable laminate implant to replace the articular disc and to test the hypothesis that the use of the implant reduces stress distribution in the condyle, implant, and glenoid fossa. A finite element model of a female human mandible, including the temporomandibular joint, which had two standard endosseous implants inserted bilaterally in the premolar region, was constructed from computed tomography scan images using a commercially available finite element software. The disc, condyle, and glenoid fossa were arbitrarily divided into five regions: the anterior, posterior, medial, lateral, and central. The disc was then replaced with a poly-L/DL-lactide biodegradable laminate. The finite element model was then used to predict principal and Von Mises stresses. The use of poly-L/DL-lactide implant resulted in remarkable reduction in Von Mises stresses (approximately threefold) in the anterior, central, and medial regions of the mandibular condyle in comparison with slight to moderate stress reductions in the corresponding regions of the implant and glenoid fossa. The mandibular condyle also demonstrated the largest total displacement in all directions followed by the implant and glenoid fossa. The use of an alloplastic implant such as the bioresorbable, poly-L/DL-lactide laminate to replace the articular disc reduces loading of the mandibular condyle rather than the implant and glenoid fossa. These findings lead to support the hypothesis that the mandibular condyle more likely functions as a shock absorber than the disc. The use of bioresorbable laminate implants might prove an efficient technique to replace the articular disc and promote normal function of the temporomandibular joint.

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Ultrastructure of the bovine temporomandibular joint disc

Cited by 26 publications

References 19 publications

An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Expression and localization of versican during postnatal development of rat temporomandibular joint disc

Effects of Tissue-Engineered Articular Disc Implants on the Biomechanical Loading of the Human Temporomandibular Joint in a Three-Dimensional Finite Element Model

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