Ultrastructure of Parietal Cells before and after Proximal Gastric Vagotomy in Duodenal Ulcer Patients

Aase, Steinar; Roland, M; Br, Olsen

doi:10.1080/00365521.1976.12097073

Scandinavian Journal of Gastroenterology

1976

DOI: 10.1080/00365521.1976.12097073

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Ultrastructure of Parietal Cells before and after Proximal Gastric Vagotomy in Duodenal Ulcer Patients

Steinar Aase¹,

M Roland²,

Olsen Br³

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Cited by 4 publications

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Formation of concentric saccules in murine parietal cells after injection of diazo‐oxo‐norleucine

Michaels

1979

Anat. Rec.

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After treatment with various chemical and physical agents, flattened or ring-like saccules may occur in the cytoplasm of parietal cells of the gastric glands of several species of mammals. In the current investigation, similar structures appeared after treatment with high dosages of diazo-oxo-norleucine (DON), a glutamine antagonist. A tentative sequence for their formation is suggested. Saccules formed of unit membrane became abundant in some parietal cells of the treated mice. Single saccules often had narrow lumens and peripheral distensions. The saccules, either singular or several stacked together, became progressively more curved, enclosing a region of cytoplasm that often contained glycogen-like particles and occasionally vesicles or other organelles. Many of the concentric saccules were close to an intracellular canaliculus. Membrane bound cytoplasm containing glycogen-like particles occasionally occurred in the canaliculi, suggesting that exocytosis had occurred. Cytochemistry revealed that glycoproteins were associated with the concentric saccules, probably located on the luminal surface. The glycogen-like particles in all locations stained in a manner characteristic of glycogen. It is suggested that the concentric saccules may form from vesicles of the tubulovesicular system.

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Formation of concentric saccules in murine parietal cells after injection of diazo‐oxo‐norleucine

Michaels

1979

Anat. Rec.

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Epithelial cell proliferation in human fundic and antral mucosae

et al. 1985

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Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. After superselective vagotomy, this correlation still existed in antral mucosa (r = 0.88, P less than 0.001) but not in fundic mucosa. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se.

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Stereological Changes in Rat Parietal Cells After Vagotomy and Antrectomy

Helander¹

1976

Gastroenterology

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Ultrastructure of Parietal Cells before and after Proximal Gastric Vagotomy in Duodenal Ulcer Patients

Cited by 4 publications

References 11 publications

Formation of concentric saccules in murine parietal cells after injection of diazo‐oxo‐norleucine

Formation of concentric saccules in murine parietal cells after injection of diazo‐oxo‐norleucine

Epithelial cell proliferation in human fundic and antral mucosae

Stereological Changes in Rat Parietal Cells After Vagotomy and Antrectomy

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