Ultrastructure of Non-Hodgkin’s Lymphomas

Kaiserling, E.

doi:10.1007/978-3-642-81092-3_5

Cited by 23 publications

(9 citation statements)

References 100 publications

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“…This finding concurs with the lack of secretory organelles (ergastoplasm) in the tumour cells (Kaiserling, 1978) and the usually decreased levels of serum Ig (Stein, 1976).…”

Section: Morphological Findingssupporting

confidence: 81%

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Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes)

Tolksdorf¹,

Stein²,

Lennert³

1980

Br J Cancer

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“…This finding concurs with the lack of secretory organelles (ergastoplasm) in the tumour cells (Kaiserling, 1978) and the usually decreased levels of serum Ig (Stein, 1976).…”

Section: Morphological Findingssupporting

confidence: 81%

“…Further evidence of a relationship between the type of lymphoma cell described here and GCC has been provided by electron-microscopical investigations (Kaiserling, 1978). In 12/20 isomorphic cases, dendritic reticulum cells were demonstrable among the tumour cells.…”

Section: Morphological Findingssupporting

confidence: 55%

Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes)

Tolksdorf¹,

Stein²,

Lennert³

1980

Br J Cancer

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“…In contrast to the other two cases in our study, evidence of ah increased rate of lymphocyte recirculation could not be found electron microscopically in the case of Lennert's lymphoma. Unlike some T-cell lymphomas-T-zone lymphoma or mycosis fungoides (Kaiserling 1977(Kaiserling , 1978)-our case of Lennert's lymphoma contained no unequivocal interdigitating reticulum cells. It remains to be seen whether this is a typical finding.…”

Section: Discussioncontrasting

confidence: 58%

Bacterial lymphadenitis with the picture of a lymphoepithelioid cell lymphoma—Lennert's lymphoma

et al. 1989

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Three cases with the typical light microscopic picture of lymphoepithelioid cell lymphoma (so-called Lennert's lymphoma) were investigated by electron microscopy. Surprisingly, Lennert's lymphoma could be excluded in two cases. These two cases exhibited, in addition to pleomorphic lymphocytes and epithelioid cells, macrophages with accumulations of bacteria, indicating that a bacterial infection was the cause of the disease. By comparing the typical case of Lennert's lymphoma with the other cases, we found several criteria for distinguishing between Lennert's lymphoma and bacterial lymphadenitis. In bacterial lymphadenitis: (1) small and medium-sized lymphocytes exhibited a wide cytological spectrum whereas the lymphocytes in Lennert's lymphoma were relatively uniform; the lymphocytes with prominent lysosome-like granules found in Lennert's lymphoma were not seen; (2) cytology and distribution of epithelioid cells were similar to those in Lennert's lymphoma; (3) epithelioid venules contained recirculating lymphocytes, which were rarely found in Lennert's lymphoma; (4) numerous interdigitating reticulum cells, fibroblasts and myofibroblasts were seen, but not in Lennert's lymphoma; (5) focal increase in reticulin fibres was the main difference in light microscopy; (6) rod-shaped bacteria were accumulated in the cytoplasm of a few macrophages. The presence of bacteria could not be demonstrated unequivocally by light microscopy. In both cases the large number of intracytoplasmic bacteria suggests that this unusual and until now unknown lymphadenitis is the result of an infection caused by facultative intracellular parasitic bacteria. The outcome of bacterial lymphadenitis that gives the false impression of Lennert's lymphoma is uncertain. Cure was achieved in one of our cases. The other patient died before therapy was commenced.

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“…4 In centroblastic/centrocytic lymphoma, FDC are found amidst neoplastic lymphocytes, not only in lymph nodes but also in other tissues involved, such as the BM.' The nature and mechanism causing the intimate association between FDC and normal or neoplastic B-lymphocytes are still unknown.…”

mentioning

confidence: 99%

Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia

Chilosi

Pizzolo

Caligaris-Cappio

et al. 1985

Cancer

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Using a sensitive immunohistochemical technique and a specific monoclonal antibody (RFD-3), follicular dendritic cells (FDC) have been demonstrated in a significant proportion (6/12) of bone marrow samples from patients with nodular marrow involvement of B-cell chronic lymphocytic leukemia (B-CLL). In all cases with "packed marrow" involvement and advanced stages of disease the FDC were absent. As these accessory cells are normally present only in the lymph nodes, their presence in the bone marrow is in accord with the view that B-CLL might be the malignancy of an immature subpopulation of lymph node lymphocytes that invade the bone marrow.

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Ultrastructure of Non-Hodgkin’s Lymphomas

Cited by 23 publications

References 100 publications

Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes)

Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes)

Bacterial lymphadenitis with the picture of a lymphoepithelioid cell lymphoma—Lennert's lymphoma

Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia

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