Ultrastructure of Myofibers and Cells Synthesizing DNA in the Developing and Regenerating Lymph-Heart Muscles

Rumyantsev, P. P.; Krylova, M. I.

doi:10.1016/s0074-7696(08)61598-3

Cited by 12 publications

(11 citation statements)

References 114 publications

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“…Also present are light-coloured cells with few filaments that resemble conductile bundles of His, found in cardiac tissue (Budras et al, 1987). Furthermore, complete automaticity has been described after denervation in amphibians (Rumyantsev and Krylova, 1990).…”

Section: Discussionmentioning

confidence: 95%

“…Despite some species-specific differences, its histological structure is similar to the striated skeletal muscle fibres (multinucleated, with peripherally located nuclei) but thinner in diameter. Some fibres branch, although they do not anastomose like cardiomyocytes (Rumyantsev and Krylova, 1990). Also present are light-coloured cells with few filaments that resemble conductile bundles of His, found in cardiac tissue (Budras et al, 1987).…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore Berens von Rautenfeld and Budras (Berens von Rautenfeld and Budras, 1981) and Budras et al (Budras et al, 1987) observed on electron micrographs of the striated lymph heart musculature in some birds that there are contracting-filament-poor fibres which resemble the conductive bundle of His of the blood heart. Amphibian denervated lymph hearts show automatic contractions 4 weeks after surgery (Rumyantsev and Krylova, 1990).…”

Section: Automaticity Of the Lymph Heartmentioning

confidence: 99%

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Lymph heart in chick - somitic origin, development and embryonic oedema

et al. 2007

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The lymph heart is a sac-like structure on either side of avian tail. In some adult birds, it empties the lymph from the copulatory organ; however,during embryonic development, it is thought to circulate extra-embryonic lymph. Very little is known about the origin, innervation and the cellular changes it undergoes during development. Using immunohistochemistry and gene expression profiling we show that the musculature of the lymph heart is initially composed solely of striated skeletal muscle but later develops an additional layer composed of smooth myofibroblasts. Chick-quail fate-mapping demonstrates that the lymph heart originates from the hypaxial compartments of somites 34-41. The embryonic lymph heart is transiently innervated by somatic motoneurons with no autonomic input. In comparison to body muscles, the lymph heart has different sensitivity to neuromuscular junction blockers (sensitive only to decamethonium). Furthermore, its abundant bungarotoxin-positive acetylcholinesterase receptors are unique as they completely lack specific acetylcholinesterase activity. Several lines of evidence suggest that the lymph heart may possess an intrinsic pacing mechanism. Finally, we assessed the function of the lymph heart during embryogenesis and demonstrate that it is responsible for preventing embryonic oedema in birds, a role previously thought to be played by body skeletal muscle contractions.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Automaticity Of the Lymph Heartmentioning

confidence: 99%

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Lymph heart in chick - somitic origin, development and embryonic oedema

et al. 2007

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“…In support of the cellular recruitment mechanism, proliferative activity is consistently higher within the compact myocardium, and there is a gradient of decreasing proliferation and increasing differentiation of myocytes from the compact towards the trabecular zone of the myocardium [Icardo and Fernandez-Teran 1987; Icardo, 1988; Rumyantsev and Krylova, 1990; Pasumarthi and Field, 2002]. P57 kip2 , a cyclin-dependent kinase inhibitor of the p21 family, is specifically expressed in the trabecular myocardium, suggesting an active process to suppress cell proliferation in the trabeculae [Kochilas et al, 1999].…”

Section: The Development Of Ventricular Wallmentioning

confidence: 99%

Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC)

Zhang¹,

Chen²,

Qu³

et al. 2013

American J of Med Genetics Pt C

122

123

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Ventricular trabeculation and compaction are two of the many essential steps for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with ventricular compact zone deficiencies (hypoplastic wall), which commonly leads to embryonic heart failure and early embryonic lethality. In contrast, hypertrabeculation and lack of ventricular wall compaction (noncompaction) are closely related defects in cardiac embryogenesis associated with left ventricular noncompaction (LVNC), a genetically heterogenous disorder. Here we review recent findings through summarizing several genetically engineered mouse models that have defects in cardiac trabeculation and compaction.

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“…In this way the activity of each lymphatic micropump could be immediately adapted to actual local demands. Clearly, contraction of lymphatic smooth muscle cells does not depend on innervation (Reddy 1986) and lymph hearts of Lissamphibia are capable of regular myogenic beating after denervation (Mislin 1972, Rumyantsev andKrylova 1990). It remains to be studied whether innervation of lymphatic micropumps in lepidosireniform Dipnoi is any more than sporadic (Fig.…”

Section: Lymphatic Micropumpsmentioning

confidence: 99%