Ultrastructure of Human Mesotheliomas
            2

Davis, J. Michael

doi:10.1093/jnci/52.6.1715

Cited by 54 publications

(5 citation statements)

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“…Mesothelioma usually stains positive with keratin immunoperoxidase, whereas adenocarcinoma is negative [94,96]. Two specimens should be preserved in glutaraldehyde for later electron microscopy if needed [32,92,[93][94][95]. HPLC analysis for hyaluronic acid should be obtained if available.…”

Section: Malignant Pleural Mesotheliomamentioning

confidence: 99%

Diagnosis and treatment of malignant pleural effusion

1987

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Pleural effusion is a common and important complication of malignancy which may at times be difficult to diagnose or treat. Its well recognized association with numerous diseases plus the limitations of our usual diagnostic tests may occasionally cause difficulty. In the oncology patient there are a number of common medical problems associated with the development of pleural effusion which frequently coexist with the malignancy. Pleural effusion may be a presenting or late sign of cancer, and when recurrent can be a vexing symptomatic problem. Fortunately, an increasing number of effective diagnostic and therapeutic modalities are available which, when judiciously applied, facilitate our approach.

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Section: Malignant Pleural Mesotheliomamentioning

confidence: 99%

Diagnosis and treatment of malignant pleural effusion

1987

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“…Many tissues are held together not by an extracellular matrix (ECM) scaffold, but by direct cell-to-cell adhesion. Such compact, three-dimensional tissues pose the problem of how the degree of adhesion required for their integrity can be combined with the presence of interstitial gaps, as seen in vertebrate embryonic tissues (1)(2)(3) or tumors (4,5). Interstitial gaps control the transport of extracellular fluid through tissues and between compartments of the body (6,7), and in solid tumors, pressure gradients in the interstitium and consequent flows of interstitial fluid pose a main problem for drug delivery (8,9).…”

Section: Introductionmentioning

confidence: 99%

Mechanics of Fluid-Filled Interstitial Gaps. II. Gap Characteristics in Xenopus Embryonic Ectoderm

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Winklbauer

2017

Biophysical Journal

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The ectoderm of the Xenopus embryo is permeated by a network of channels that appear in histological sections as interstitial gaps. We characterized this interstitial space by measuring gap sizes, angles formed between adjacent cells, and curvatures of cell surfaces at gaps. From these parameters, and from surface-tension values measured previously, we estimated the values of critical mechanical variables that determine gap sizes and shapes in the ectoderm, using a general model of interstitial gap mechanics. We concluded that gaps of 1-4 μm side length can be formed by the insertion of extracellular matrix fluid at three-cell junctions such that cell adhesion is locally disrupted and a tension difference between cell-cell contacts and the free cell surface at gaps of 0.003 mJ/m is generated. Furthermore, a cell hydrostatic pressure of 16.8 ± 1.7 Pa and an interstitial pressure of 3.9 ± 3.6 Pa, relative to the central blastocoel cavity of the embryo, was found to be consistent with the observed gap size and shape distribution. Reduction of cell adhesion by the knockdown of C-cadherin increased gap volume while leaving intracellular and interstitial pressures essentially unchanged. In both normal and adhesion-reduced ectoderm, cortical tension of the free cell surfaces at gaps does not return to the high values characteristic of the free surface of the whole tissue.

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“…Die gegenstandlichen zwei Mesotheliome waren nach dieser Einteilung den gemischten (biphasischen) Formen zuzurechnen. Die ultrastrukturelle Untersuchung von menschlichen Mesothelzellen erbrachte den Nachweis folgender Strukturen: Groi3e Kerne mit zahlreichen Einbuchtungen, mitunter sogar mit Lappung, reichlich rauhes endoplasmatisches Retikulum, weniger zahlreich Mitochondrien, glattes endoplasmatisches Retikulum und Golgi-Apparat, reichlich Tonofilamente, mitunter Glykogen-und Lipidgranula, Zytoplasmafortsatze, Mikrovilli, zwischen den Zellen Spaltraume, in die die Mikrovilli hineinragen, Desmosomen und Tight junctions, Vakuolen, in die ebenfalls Mikrovilli ragen und schliefilich eine mehr oder weniger kontinuierliche Basallamina (WANG, 1973;DAVIS, 1974;SUZUKI u. Mitarb., 1976;KUHN, 1979;MCCAUGHEY u.…”

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“…Bei Adenokarzinomzellen finden sich Mikrovilli in der Regel nur an der freien Oberflache der Zellen, die das Drusenlumen begrenzt; die Lateralflachen liegen in dichtem Kontakt mit der jeweiligen Nachbarzelle. Bei Mesotheliomzellen finden sich Mikrovilli an allen freien Oberflachen, und zwischen zwei benachbarten Zellen bleiben Spaltraume frei, in die mitunter Mikrovilli hineinragen (DAVIS, 1974;WARHOL u. Mitarb., 1982).…”

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Sklerosierende Mesotheliome beim Hund

Loupal

1987

Journal of Veterinary Medicine Series A

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Sclerosing mesothelioma in the dogTwo cases of sclerosing mesothelioma in dogs are described: In these tumours massive proliferation of connective tissue is combined with a relative by small amount of neoplastic mesothelial cells which lie eigher solitarily or in small groups, focally even in larger epithelial formations in the proliferated connective tissue. The mesothelial character of these tumour cells was proved by the ultrastructural demonstration of desmosomes, clefts between the cells, indented nuclei, microvilli and vacuoles with microvilli. Sclerosing mesotheliomas in dogs seem to occur especially in male alsatians.

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Ultrastructure of Human Mesotheliomas 2

Cited by 54 publications

References 0 publications

Diagnosis and treatment of malignant pleural effusion

Diagnosis and treatment of malignant pleural effusion

Mechanics of Fluid-Filled Interstitial Gaps. II. Gap Characteristics in Xenopus Embryonic Ectoderm

Sklerosierende Mesotheliome beim Hund

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