Ultrastructure of developing melanosomes in C57 Black and pallid mice

The Melanin Affinity of Chloroquine and Chlorpromazine Studied by Whole Body Autoradiography

“…The anatomy of the inner ear is similar to that of the eye in the respect that melanin bearing cells are situated in the vicinity of the sensory cells. Heavy deposits of melanin are normally present in the planum semilunatum adjacent to the crista ampullaris and in the stria vascularis in the cochlea (Corti 1851;Wolff 1931;Engstrom et al 1955;Beck 1961;Catalan0 & Madonia 1963;Borghesan 1964;Savin 1965;Theriault & Hurley 1970;Deol 1971). The antimalarial quinine, which has been shown by Potts (1964) to have affinity for melanin, is known lo damage both the retinal pigment epithelium and the stria vascularis, causing pigmentary retinopathy and deafness (Dekking 1949;Hennebert & Fernlindez 1959;Grant 1962;Knox et al 1966;Kahrweg & Schmidt 1968).…”

The Coat Colors of Mice

“…Occurrence and Structure of Pigment Granules Theriault and Hurley (1970) have compared the occurrence and ultrastructure of developing melanosomes in the retinal epithelium, the sensory epithelium of the inner ear, and the epidermis of pallid (a/a;pa/pa) mice with those of C57BLjl0 (a/a) animals (see also Hearing et aI., 1970). They found that in 14-day-old a/a embryos there were melanosomes in all stages of development in the retinal epithelium and pigment granules were present in the utricular epithelium, whereas in pal pa embryos no melanosomes occurred in the inner ear and only premelanosomes were present in the retinal epithelium.…”

Mouse Models of Hermansky Pudlak Syndrome: A Review

“…In contrast, the eumelanin granules of the hair of the light ear and pale ear mutants are smaller than normal (Lane and Green, 1967). The mouse HPS mutant with the greatest degree of pigment dilution, pallid, has a conspicuous reduction, and in some tissues an apparent absence, of melanosomes (Theriault and Hurley, 1970;Hearing et al, 1973) though pigment cells have a normal DOPA reaction (It0 et al, 1993). When melanosomes are present, they tend to be of early developmental stages I and I1 premelanosomes.…”