Ultrastructure of age changes in the basal infoldings of aged mouse retinal pigment epithelium

Mishima, Hiromu K.; Kondo, Kazuyoshi

doi:10.1016/s0014-4835(81)80083-8

Cited by 14 publications

(14 citation statements)

References 11 publications

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“…There have been several reports of agerelated changes in the RPE and/or Bruch's membrane of rats [20] and mice [4,5,8,15,22,27,[29][30][31][32]42]. Some of these reports describe unusual changes in the basal infoldings and basement membrane of rodents that develop between 1 and 2 years of age [20,30,31]. We find a similar pattern of age-related changes in the Rpe65 / mouse, but the alterations occur earlier and more extensively than in wild-type mice.…”

Section: Introductionsupporting

confidence: 68%

“…They also noted areas of loss of basal infoldings. In both studies [20,31] these changes appeared only in animals that were more than 1 year old. We have found similar changes in the Rpe65 / mutant which appear much earlier, being detectable at 6 months of age.…”

Section: Discussionmentioning

confidence: 88%

“…Age produces characteristic changes in the basal surface of RPE of wild-type mice [30,31] and rats [20]. Mishima and Kondo [31] considered that these changes were due to a fusion of the plasma membranes of the basal infoldings of the RPE cell.…”

Section: Discussionmentioning

confidence: 99%

“…Mishima and Kondo [31] considered that these changes were due to a fusion of the plasma membranes of the basal infoldings of the RPE cell. Katz and Robison [20] noted a thickening of the basement membrane of RPE as well as an enlargement and prolongation of the basal infoldings.…”

Section: Discussionmentioning

confidence: 99%

“…It would be valuable to have models for these changes in the RPE and Bruch's membrane in small animals, such as rodents, which occur over a more rapid time course, providing a greater range of possible experimentation. There have been several reports of agerelated changes in the RPE and/or Bruch's membrane of rats [20] and mice [4,5,8,15,22,27,[29][30][31][32]42]. Some of these reports describe unusual changes in the basal infoldings and basement membrane of rodents that develop between 1 and 2 years of age [20,30,31].…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in the basement membrane of the retinal pigment epithelium of Rpe65 ?/? and wild-type mice

Ivert

Keldbye

Gouras

2004

Graefe's Arch Clin Exp Ophthalmol

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Section: Introductionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Age-related changes in the basement membrane of the retinal pigment epithelium of Rpe65 ?/? and wild-type mice

Ivert

Keldbye

Gouras

2004

Graefe's Arch Clin Exp Ophthalmol

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Development and degeneration of retina in rds mutant mice: Electron microscopy

Jansen

Sanyal

1984

J of Comparative Neurology

150

104

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In the retina of mice homozygous for the retinal degeneration slow (rds) gene, receptor outer segments failed to develop and typical disc structures were never observed. However, cilia surrounded by a plasma membrane were regularly present. At the time when outer segments grew in the normal retina, the optic ventricle in the mutant showed an accumulation of membrane-bound vesicles of varying size and density. The vesicles declined in frequency at later stages of degeneration. After initial growth, the inner segments in the mutant retina remained stunted but maintained their morphological differentiation, including the ciliary structures. Their number declined with loss of visual cells. In the mutant retina development of synapses, between the receptor cells and the processes of the horizontal cells and the bipolar cell dendrites, followed in normal sequence. Formation of spherule terminals of the rods, with one triad synapse, and of pedicle terminals of the cones, with multiple triad synapses, was recorded in the same way as in the normal retina. With loss of visual cells in the mutant retina, some of the profiles of the surviving spherule terminals showed an increased occurrence of two, three, or more synaptic sites. This growth resulted from enlargement and branching of the ribbons and sprouting from the postsynaptic elements. Similar changes were not observed in the pedicle terminals. The pigment epithelial cells in the mutant mice appeared initially normal, but phagolysosomal structures were absent. However, various inclusion bodies appeared within the pigment epithelial cells following degenerative changes in the retina. In some places, the basal infoldings deepened their furrows while thinning the cytoplasmic part of the epithelium. Failure to form the outer segments and the subsequent lysis of the visual cells appear to be the primary effects of the rds gene, whereas the synaptic growth in the sperule terminals and the changes in the pigment epithelium appear to be consequential to those defects.

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