Ultrastructure of a human malignant IgA-producing plasmacytoma

Curtis, Sherill K.; Propp, Richard P.; Cowden, Ronald R.; Tartaglia, Anthony P.

doi:10.1016/0014-4800(75)90083-0

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…However, due to the lack of evidence of osteoid, which should be found in small amounts even in a "nonproductive osteoblastic osteosarcoma" (Thompson and Dittmer 2017b), as well as the rather atypical localization for the horse (Bushet al 2007;Thompson and Dittmer 2017b), this seems unlikely. In particular, the tumour cell invasion into the vertebral canal (Thompson and Dittmer 2017a) as well as the morphology typical for plasma cells on an ultrastructural level such as an eccentric nucleus, much cytoplasm with abundant rough endoplasmic reticulum with partially dilated cisternae (Curtis et al 1975) suggest a plasma cell tumour as cell of origin.…”

Section: Discussionmentioning

confidence: 99%

Paramedullary plasmacytoma originating from the first cervical vertebra (C1) in an 8-month-old warmblood weanling with tetraparesis: Clinical and pathological findings

Schiffbauer

Pelli

Tommasa

et al. 2022

Preprint

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To the authorsʼ knowledge there is only one report in the literature, dealing with paramedullary plasmacytomas in horses as so-called “break out lesions”, originating from the bone marrow of a vertebra and invading the epidural space (Drew and Greatorex 1974). Our case report describes the clinical and patho-morphological findings of such a case. The affected 8-month-old warmblood weanling colt exhibited acute tetraparesis thus, a spinal cord lesion in the cervical column was suspected. Computed tomography revealed osteolytic lesions in C1 and a heterogeneous mass within the respective segment of the vertebral canal. By means of patho-morphological examination, with the aid of transmission electron microscopy, a plasmacytoma was identified, that had grown out of the bone marrow of C1 into the epidural space, locally compressing the spinal cord. In tetraparetic, young horses traumatic spine cord injuries, cervical vertebral malformations and infectious diseases of the central nervous system represent common differentials. However bone-dissolving tumours such as paramedullary plasmacytomas should be considered as a further possible cause in the presence of severe neurological deficits.

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Section: Discussionmentioning

confidence: 99%

Paramedullary plasmacytoma originating from the first cervical vertebra (C1) in an 8-month-old warmblood weanling with tetraparesis: Clinical and pathological findings

Schiffbauer

Pelli

Tommasa

et al. 2022

Preprint

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“…4 Therefore, they require extensive development of the secretory pathway cellular structures, including the endoplasmic reticulum (ER), the polyribosomes and secretory vesicles, and accordingly, they exhibit an increased cytoplasmic-to-nuclear ratio compared with the B-cell progenitors. 5 Igs are confined to small carrier vesicles before secretion 6 and are constitutively secreted from the cell into the extracellular space through the classical secretory pathway. 7 The cell membrane fusion and, particularly, the fusion between secretory vesicles and the plasma membrane for exocytosis must be specific to maintain organelle identity, cell function and viability, and it requires a molecular mechanism to juxtapose and fuse the two membranes involved.…”

Section: Introductionmentioning

confidence: 99%

VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

et al. 2016

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The production and secretion of antibodies by human plasma cells (PCs) are two essential processes of humoral immunity. The secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), which are located in the plasma membrane (t-SNAREs) and in the antibody-carrying vesicle membrane (v-SNARE), and mediate the fusion of both membranes. We have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody secretion. Here, using human PCs and antibody-secreting cell lines, we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein (VAMP) isoforms, demonstrating that all isoforms (with the exception of VAMP1) are expressed by the referenced cells. Furthermore, the functional role in antibody secretion of each expressed VAMP isoform was tested using siRNA. Our results show that VAMP2 may be the v-SNARE involved in vesicular antibody release. To further support this conclusion, we used tetanus toxin light chain to cleave VAMP2, conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles, and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with STX4. Taken together, these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

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Multiple Myeloma

Levin¹

1977

Arch Ophthalmol

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Ultrastructure of a human malignant IgA-producing plasmacytoma

Cited by 8 publications

References 21 publications

Paramedullary plasmacytoma originating from the first cervical vertebra (C1) in an 8-month-old warmblood weanling with tetraparesis: Clinical and pathological findings

Paramedullary plasmacytoma originating from the first cervical vertebra (C1) in an 8-month-old warmblood weanling with tetraparesis: Clinical and pathological findings

VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

Multiple Myeloma

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