Ultrastructure and origin of adenocarcinomas detected in the lungs of three cows

Kadota, Koichi; Ito, Koichi; Kamikawa, Sadanori

doi:10.1016/0021-9975(86)90036-8

Cited by 2 publications

(4 citation statements)

References 4 publications

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“…Systolic murmur and tachycardia may be observed when there is cardiac impairment due to metastasis (7). In other affected species, clinical signs tend to be similar (2,8,11,16). The most important macroscopic and microscopic findings observed in this case, such as splenomegaly, hemolysis, hemoglobinuria, red pulp hyperplasia, hemosiderosis, nephrosis, intra-erythrocyte parasitic structures compatible with Babesia sp., are indicative of equine babesiosis.…”

Section: Discussionmentioning

confidence: 61%

“…Primary pulmonary carcinomas have already been described in equines (4, 7), bovines (8,16), rodents (1), dogs (2) and cats (13). Although considered a disease of older animals (12), lung carcinomas have been reported in equines between 4 (7) and 23 years (4).…”

Section: Discussionmentioning

confidence: 99%

“…In equines, metastasis has been reported to lymph nodes, mediastinum, adrenal glands, heart, blood vessels, kidneys, muscles and distant lymph nodes (7,14). In bovines, masses tend to be multiple, up to 10 cm in diameter, eventually forming a large mass encompassing the mediastinal and epigastric lymph nodes and part of the liver (8,16). Frequently, pulmonary carcinomas in bovines are incidental findings at slaughterhouses (8,19).…”

Section: Discussionmentioning

confidence: 99%

“…In bovines, masses tend to be multiple, up to 10 cm in diameter, eventually forming a large mass encompassing the mediastinal and epigastric lymph nodes and part of the liver (8,16). Frequently, pulmonary carcinomas in bovines are incidental findings at slaughterhouses (8,19). Differently from farm animals, in dogs and cats neoplastic masses are usually multiple, ranging from 0.3 cm to 5 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Pulmonary adenocarcinoma in mare

Faccin¹,

Cestari²,

Matos³

et al. 2018

BJVP

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Primary lung neoplasms are infrequent in veterinary medicine, particularly in large animals. The most frequently affected species are dogs and cats. These neoplasias are usually malignant and the adenocarcinoma type is the most frequent. This paper describes a case of pulmonary adenocarcinoma in a mare, including its pathological and immunohistochemical features. The animal had natural death and was submitted for necropsy. Diffuse jaundice, splenomegaly due to red pulp hyperplasia, pulmonary edema and congestion were observed. Cytological evaluation of the spleen revealed intracytoplasmatic structures in erythrocytes, compatible with Babesia sp. Histopathology of the lung revealed a neoplastic proliferation of epithelial cells, forming acinar and tubular structures supported by a fibrovascular stroma. Immunohistochemistry of such lesions was positive for cytokeratin and napsin A, negative for vimentin and thyroid transcription factor 1, corroborating the diagnosis of adenocarcinoma. Lung carcinomas in equines are described in animals ranging from four to 23 years old, without breed or sex predisposition. Clinical signs, when present, are related to the compromise of respiratory function, which was not observed in the present case. Pulmonary neoplasms must be considered among the diagnostics of chronic respiratory diseases. Histopathological and immunohistochemistry exams are highly valuable for classification of primary lung neoplasms.

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