Ultrastructural Study of Induced Keratinization in Sulcular Gingival Epithelium in Rhesus Monkeys

Kristoffersen, Einar K.; Caffesse, Raúl G.; Nasjleti, Carlos E.; Kristoffersen, T.

doi:10.3109/00016358309162329

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…AIthoug this may be an important finding itself, its bearing on the interpretation of the results of the present study is rather limited, given the absence of a significant correlation between initial and final stage in the respects tnentioned above. However, a possibly pre-existing indammatory infiltrate and the state of the epithelium tiiay have had some bearing on the different rates of development of gingivitis in the 2 groups (Schroeder et al, 1975, Kristoffersen et al, 1983, An analysis of plaque cotnposition was outside the scope of the present study. The few reports on plaque composition found in the literature either reveal no great differences in this respect between DS children and controls or involved institutionalized children (Reuland-Bosma & Van Dijk 1986), It is more likely that the host reaction in DS children with their functional defects in PMN, tnonocytes and lymphocytes, is responsible for the difference in gingival inflammation found (Wittingham et al, 1977, Barkin et al, 1980a.…”

Section: Discussionmentioning

confidence: 87%

Experimental gingivitis around deciduous teeth in children with Down's syndrome

Reuland-Bosma

Dijk

Weele

1986

J Clinic Periodontology

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Epidemiological studies have shown that there is a high prevalence and rapid progression of periodontal disease in children with Down's Syndrome (DS). In this respect, DS children exhibit a markedly different response compared with healthy children. In order to understand the reasons for this difference, a controlled study was set up to determine the extent and the quality of the differences in the early periodontal tissue response towards dental plaque in the deciduous dentition of DS children and matched control children. In a preliminary investigation, the gingival health was estimated by determining the bleeding tendency. 9 healthy children were selected from a group of 14 and matched with 9 DS children with respect to plaque development, sulcus depth and age. The DS children had a higher bleeding tendency than the matched controls. In the DS children, moreover, a correlation was found between bleeding tendency and age. No such correlation was found in the controls. After a period of intensive oral hygiene, all cleaning of teeth was discontinued for 21 days. The amount of plaque according to the plaque index, the gingival health according to the gingival index, and the amount of crevicular leucocytes and gingival exudate were assessed at days 0, 7, 14 and 21. During the experimental phase of the study, the amount of plaque increased at a similar rate in both groups. In the DS children, the development of gingival inflammation started earlier and was more extensive. It increased after day 14, whereas in the control children, the gingival inflammation seemed to stabilize at this time. The results of the present experimental study thus confirm earlier results from epidemiological studies.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 87%

Experimental gingivitis around deciduous teeth in children with Down's syndrome

Reuland-Bosma

Dijk

Weele

1986

J Clinic Periodontology

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“…The reason for an earlier and a more rapid gingival response to denial plaque is not known; abnormalities in host defense may be of importance (Breg 1977). A faster gingival inflammation may aiso be the result of aberrant morphology of the gingival epithelium (Cohen et al 1961. Kristoffersen et al 1983, The presence in DS of systemic alterations affecting connective tissue and vascularisation, has been suggested (Cohen et al 1961, Claycomb et al 1970, Kontras & Bodenbender 1966.…”

mentioning

confidence: 99%

Morphological aspects of the gingiva in children with Down's syndrome during experimental gingivitis

Reuland-Bosma

Liem

Jansen

et al. 1988

J Clinic Periodontology

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In a previous investigation, children with Down's syndrome (DS) showed an earlier, more rapid and more extensive gingival inflammation than normal healthy control children. These differences in gingival inflammation may be the result of aberrant morphology of the gingiva related to the genetic disorder in DS children. The aims of the present study were (i) to describe the structural composition of "normal" gingiva in DS compared to control children, (ii) to analyse the histological changes in the gingiva during plaque development and (iii) to investigate whether the clinical findings could be supported by morphological observations. The study was carried out in 8 DS and 8 matched control children. Their ages ranged from 5-10 years. Gingival normality was guaranteed by strict oral hygiene procedures. During a period of 21 days in which oral hygiene was abolished, gingival biopsies were taken from buccal sites of deciduous teeth following a predetermined schedule on days 0, 7, 14 and 21. Results on day 0 showed no morphological differences between the DS and control children regarding oral epithelium, junctional epithelium or connective tissue. During the experimental phase of the study, the amount of plaque accumulation in the DS children gave rise to a more extensive gingival inflammation than in the control children. The gingival inflammation in the DS group started earlier and included: (1) an acute inflammatory response, (2) an increase of the junctional epithelium area, (3) an increase of the infiltrated connective tissue area (ICT) and (4) a decrease in collagen fibre density of about 35-40% compared to day 0. The same phenomena were not seen until 7 days later in the control group. Conversely, the development of a perivascular lymphocyte infiltrate (LI) in the DS children was delayed compared to the control group. This may be caused by the impaired delayed-type hypersensitivity response in DS children. The development of 2 separate infiltrates (ICT and LI) in this age group and the different temporal development of ICT (day 7 for the DS and day 14 for the control group) and LI (day 14 for the DS and day 7 for the control group) does suggest different immunological mechanisms for both areas and both groups.

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“…However, with a strict regimen of oral hygiene and antibiotics in monkeys it has been shown that the sulcular epithelium can become keratinized (Kristoffersen, Caffesse et al 1983). The base of the gingival sulcus gives rise to the junctional epithelium.…”

Section: VIImentioning

confidence: 99%

Efficacy of socket grafting for alveolar ridge preservation

Gubler¹

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Tooth extraction initiates a cascade of events that often leads to local anatomic changes in the alveolar ridge. Ridge preservation is a surgical approach aimed at minimizing hard and soft tissue volume loss. There have been contradicting reports on the efficacy of socket grafting for alveolar ridge preservation. Interestingly, there is a paucity of adequately powered randomized controlled clinical trials. The purpose of this study was to assess the effect of the application of a socket grafting technique on alveolar ridge dimensional changes following tooth extraction. Methods: Healthy patients requiring the extraction of one single-rooted tooth on either arch, from second premolar to second premolar, excluding mandibular incisors, and who met the eligibility criteria were recruited. Patients were then randomly assigned to either the control group, consisting of tooth extraction alone, or the experimental group, which consisted of extraction and simultaneous ridge preservation using an allograft bone material to fill the socket and a dense polytetrafluoroethylene membrane (dPTFE) to seal it. Cone beam computed tomography (CBCT) was obtained immediately prior to extraction (baseline) and at 14 weeks. Linear measurements with the use of a toothsupported stent were obtained immediately after extraction (baseline) and at 14 weeks. Linear and volumetric measurements were made using data obtained from the CBCTs. Masked, calibrated examiners performed all radiographic measurements. Measurements obtained included buccal keratinized tissue width, buccal and lingual plate height and width, alveolar ridge horizontal width (CBCT); and alveolar ridge volume changes.

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Ultrastructural Study of Induced Keratinization in Sulcular Gingival Epithelium in Rhesus Monkeys

Cited by 7 publications

References 35 publications

Experimental gingivitis around deciduous teeth in children with Down's syndrome

Experimental gingivitis around deciduous teeth in children with Down's syndrome

Morphological aspects of the gingiva in children with Down's syndrome during experimental gingivitis

Efficacy of socket grafting for alveolar ridge preservation

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