Ultrastructural similarity of endocrine-like cells of the human lung and some related cells of the gut

Capella, Carlo; Häge, Esther; Solcia, Enrico; Usellini, L.

doi:10.1007/bf00219652

Cited by 73 publications

(32 citation statements)

References 41 publications

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“…Larsson et al (1976b) described that the granules of D1-cells had fairly low electron density, this is in agreement with our more recent observations for ghrelin cells (Wierup & Sundler 2005). Capella et al (1978) reported that P/D1-cells were numerous in the foetal pancreas, but rare in the adult pancreas. They also showed that the cells are numerous in foetal pancreas, while few in the stomach (Capella et al 1978).…”

Section: Double-or Triple-immunostained Foetal Human Islets (22 Weekssupporting

confidence: 90%

“…Thus, the pattern of developmental regulation (Wierup et al 2002) and granule properties (Wierup & Sundler 2005) for ghrelin cells fits well with the previously described 'hormoneless' pancreatic P/D1-cells (Larsson et al 1976b, Capella et al 1978, Bordi et al 1986, Sundler & Hå kanson 1988. Larsson et al (1976b) described that the granules of D1-cells had fairly low electron density, this is in agreement with our more recent observations for ghrelin cells (Wierup & Sundler 2005).…”

Section: Double-or Triple-immunostained Foetal Human Islets (22 Weekssupporting

confidence: 87%

“…Thus, serotonin-producing enterochromaffin (EC)-cells, thought to correspond to the EC-cells of the gut, are regularly seen dispersed in the pancreas in certain species, e.g. the pig (Capella et al 1978, Alumets et al 1983) and gastrinproducing G-cells have been demonstrated in the rat pancreas during neonatal development, while such cells are present, albeit in small numbers, in the pancreas of adult cat and dog (Larsson et al 1976a). Recently, G-cells have also been found to be a distinct islet cell type in mice during development (Suissa et al 2013).…”

Section: Enterochromaffin-cells and G-cellsmentioning

confidence: 99%

“…Hence, cells with small granules, such as the P-cell (Capella et al 1978) and the D1-cell (Larsson et al 1976b), collectively referred to as P/D1-cells (Rindi et al 2002a), are present in the human islets. One report also described small granule cells in human pancreas as type VI cells (Jirasek & Kubes 1972).…”

Section: Morphologically Characterised Cells Without Known Hormonal Cmentioning

confidence: 99%

“…One report also described small granule cells in human pancreas as type VI cells (Jirasek & Kubes 1972). These cells were all characterised merely with respect to ultrastructure and the hormone product has remained unknown for more than three decades (Larsson et al 1976b, Capella et al 1978, Bordi et al 1986, Solcia et al 1987, Sundler & Håkanson 1988.…”

Section: Morphologically Characterised Cells Without Known Hormonal Cmentioning

confidence: 99%

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The islet ghrelin cell

Wierup¹,

Sundler²,

Heller³

2013

Journal of Molecular Endocrinology

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The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centuries. During the twentieth century several different cell types were described in the islets of different species and at different developmental stages. Six cell types with identified hormonal product have been described so far by the use of histochemical staining methods, transmission electron microscopy, and immunohistochemistry. Thus, glucagon-producing a-cells, insulin-producing b-cells, somatostatin-producing d-cells, pancreatic polypeptide-producing PP-cells, serotoninproducing enterochromaffin-cells, and gastrin-producing G-cells have all been found in the mammalian pancreas at least at some developmental stage. Species differences are at hand and age-related differences are also to be considered. Eleven years ago a novel cell type, the ghrelin cell, was discovered in the human islets. Subsequent studies have shown the presence of islet ghrelin cells in several animals, including mouse, rat, gerbils, and fish. The developmental regulation of ghrelin cells in the islets of mice has gained a lot of interest and several studies have added important pieces to the puzzle of molecular mechanisms and the genetic regulation that lead to differentiation into mature ghrelin cells. A body of evidence has shown that ghrelin is an insulinostatic hormone, and the potential for blockade of ghrelin signalling as a therapeutic avenue for type 2 diabetes is intriguing. Furthermore, ghrelin-expressing pancreatic tumours have been reported and ghrelin needs to be taken into account when diagnosing pancreatic tumours. In this review article, we summarise the knowledge about islet ghrelin cells obtained so far.

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Section: Double-or Triple-immunostained Foetal Human Islets (22 Weekssupporting

confidence: 90%

Section: Double-or Triple-immunostained Foetal Human Islets (22 Weekssupporting

confidence: 87%

Section: Enterochromaffin-cells and G-cellsmentioning

confidence: 99%

Section: Morphologically Characterised Cells Without Known Hormonal Cmentioning

confidence: 99%

Section: Morphologically Characterised Cells Without Known Hormonal Cmentioning

confidence: 99%

See 3 more Smart Citations

The islet ghrelin cell

Wierup¹,

Sundler²,

Heller³

2013

Journal of Molecular Endocrinology

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Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Scheuermann

1997

Microsc. Res. Tech.

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It is increasingly recognized that neuroepithelial endocrine cells and organoid clusters of these cells termed neuroepithelial bodies are widely distributed in the respiratory tract of vertebrates. This review focuses on the neuroepithelial endocrine system in the airway epithelium of mammals according to observations made in a wide range of species, as it appears in light and electron microscopy by means of various visualization techniques under normal and experimental conditions. Because there are similarities but also marked differences between species, wherever possible studies in human airways are emphasized. Conventional histochemical and ultrastructural studies including microspectrofluorimetry have demonstrated the amine‐handling properties and the presence of neurosecretory granules in neuroendocrine cells of the epithelium of all mammals studied so far. The neuroepithelial bodies are innervated by morphological afferent‐ and efferentlike synaptic specializations. These, together with the presence of reciprocal synapses, emphasize that these cells may be involved in dual functions of chemoreception and secretion. Light and electron microscopic immunohistochemistry has demonstrated that neuroepithelial endocrine cells may contain various biogenic agents, suggesting that the neuroendocrine system is highly heterogeneous. Neural elements may interact in a complex manner, and the activation of certain neural pathways may control the release of biogenic substances to influence physiological airway functions. They may be particularly relevant in pulmonary diseases. Consequently, the function of this system is complex and it is highly probable that many of its aspects are still not elucidated. Microsc. Res. Tech. 37:31–42, 1997. © 1997 Wiley‐Liss, Inc.

show abstract

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Scheuermann¹

1997

Microsc. Res. Tech.

View full text Add to dashboard Cite

It is increasingly recognized that neuroepithelial endocrine cells and organoid clusters of these cells termed neuroepithelial bodies are widely distributed in the respiratory tract of vertebrates. This review focuses on the neuroepithelial endocrine system in the airway epithelium of mammals according to observations made in a wide range of species, as it appears in light and electron microscopy by means of various visualization techniques under normal and experimental conditions. Because there are similarities but also marked differences between species, wherever possible studies in human airways are emphasized. Conventional histochemical and ultrastructural studies including microspectrofluorimetry have demonstrated the amine-handling properties and the presence of neurosecretory granules in neuroendocrine cells of the epithelium of all mammals studies so far. The neuroepithelial bodies are innervated by morphological afferent- and efferentlike synaptic specializations. These, together with the presence of reciprocal synapses, emphasize that these cells may be involved in dual functions of chemoreception and secretion. Light and electron microscopic immunohistochemistry has demonstrated that neuroepithelial endocrine cells may contain various biogenic agents, suggesting that the neuroendocrine system is highly heterogeneous. Neural elements may interact in a complex manner, and the activation of certain neural pathways may control the release of biogenic substances to influence physiological airway functions. They may be particularly relevant in pulmonary diseases. Consequently, the function of this system is complex and it is highly probable that many of its aspects are still not elucidated.

show abstract

Ultrastructural similarity of endocrine-like cells of the human lung and some related cells of the gut

Cited by 73 publications

References 41 publications

The islet ghrelin cell

The islet ghrelin cell

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

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