Ultrastructural properties of rat tail tendon

Price, J.P.; Njus, Glen O.; Conway, Ted

doi:10.1109/sbec.1996.493275

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Stress-strain data for the rat tail tendon fascicles was within the range reported in the literature 21 of 0 to 20 MPa for strains of 0 to 5%. This suggests that our stress and strain measurements were accurate and provide a good reference between collagen crimp period, applied strain and resulting stress in the tissue.…”

Section: Discussionsupporting

confidence: 83%

Optical coherence tomography imaging of collagenous tissue microstructure

2000

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The engineering of new biomaterials requires an in-depth understanding of the structure and function of the native tissues. Optical coherence tomography (OCT) is a non-destructive technique that allows the visualization of the microstructure of biological tissues. The aim of this study was to determine if OCT could be used to identify geometric properties of tendons such as crimp pattern. Freshly harvested tendon tissue was imaged with OCT during the application of incremental axial strain. Loads were simultaneously recorded during imaging. Results revealed that birefringent banding perpendicular to the collagen fiber axis could be visualized and measured. This crimp banding disappeared at a very low strain. Birefringent banding parallel to the collagen fiber axis was also seen and it was observed that the number of parallel bands increased as strain increased. Stress-strain data was calculated and found to lie within the expected range. These results indicate that OCT may prove to be a useful tool for the non-destructive analysis of tissue microstructure.

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Section: Discussionsupporting

confidence: 83%

Optical coherence tomography imaging of collagenous tissue microstructure

2000

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“…This also explains the long appearance of the toe region in our data in comparison with the literature. If the data reported by Price et al (1996) is adjusted to consider for an additional 2% strain experienced prior to removing crimp, then the two data sets are in agreement.…”

Section: Discussionmentioning

confidence: 99%

“…Kastelic considered the beginning point to be when the specimen first appeared to be taut. Others (Price et al 1996) began their measurements once the crimp disappeared. The present study demonstrated that small loads were distinguishable just before the fascicle appeared taut.…”

Section: Discussionmentioning

confidence: 99%

Recruitment of Tendon Crimp With Applied Tensile Strain

Hansen

Weiss

Barton

2001

Journal of Biomechanical Engineering

270

199

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The tensile stress-strain behavior of ligaments and tendons begins with a toe region that is believed to result from the straightening of crimped collagen fibrils. The in situ mechanical function is mostly confined to this toe region and changes in crimp morphology are believed to be associated with pathological conditions. A relatively new imaging technique, optical coherence tomography (OCT), provides a comparatively inexpensive method for nondestructive investigation of tissue ultrastructure with resolution on the order of 15 microm and the potential for use in a clinical setting. The objectives of this work were to assess the utility of OCT for visualizing crimp period, and to use OCT to determine how crimp period changed as a function of applied tensile strain in rat tail tendon fascicles. Fascicles from rat tail tendons were subjected to 0.5 percent strain increments up to 5 percent and imaged at each increment using OCT. A comparison between OCT images and optical microscopy images taken between crossed polarizing lenses showed a visual correspondence between features indicative of crimp pattern. Crimp pattern always disappeared completely before 3 percent axial strain was reached. Average crimp period increased as strain increased, but both elongation and shortening occurred within single crimp periods during the application of increasing strain to the fascicle.

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Ultrastructural properties of rat tail tendon

Cited by 2 publications

References 7 publications

Optical coherence tomography imaging of collagenous tissue microstructure

Optical coherence tomography imaging of collagenous tissue microstructure

Recruitment of Tendon Crimp With Applied Tensile Strain

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