Ultrastructural Observations on Surgically Produced Partial-thickness Defects in Articular Cartilage

Platelet interaction with modified articular cartilage. Its possible relevance to joint repair.

“…5 lycan aggre-could be achieved in rabbit joints by analogous methods. As reported in detail elsewhere (26,27) scarifications restricted to the knee joint cartilage ome notice-of rabbits and not entering subchondral bone (28) GS is more showed no evidence of inflammation or repair no sites on the matter how long after arthrotomy such lesions were ttelets. Since examined.2 In the present study, no platelets or roups on the fibrin were seen to adhere to the cartilage surface tant role in 48 h after the intraarticular injection of 0.5 ml of since it had heparinized whole blood, although a few morphologiis a potent cally unaltered erythrocytes and leukocytes were f interest to present in the space created by the lesion (Figs.…”

Titanium implants in rabbit knee joints

“…Superficial cartilage defects do not appear to heal (Meachim 1963, Fuller & Ghadially 1972, Salter et al 1980. In contrast, full-thickness defects heal, possibly by proliferation of undifferentiated subchondral marrow cells (De Palma et al 1966, Meachim & Roberts 1971, Mitchell & Shepard 1976.…”

Gene-based approaches for the repair of articular cartilage

“…These can often expand with time and use, and lead to the more generalized cartilage loss associated with OA. [1][2][3] A repair response can occur when injury extends through the chondral layer to the subchondral bone and underlying vasculature. Local bleeding and fibrin clot formation causes an infiltration of bone marrow-derived cells which synthesize space-filling repair tissue ( Figure 1).…”