Ultrastructural morphometric analysis of the unstimulated adrenal cortex of rats

Rohr, H.P.; Bartsch, Georg; Eichenberger, Patrick M.; Rasser, Y.; Kaiser, Ch.; Keller, M.

doi:10.1016/s0022-5320(76)80003-2

Cited by 22 publications

(4 citation statements)

References 22 publications

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“…The methodological divergence of the two studies may be the reason behind the differences in results. Rohr et al 15 reported volume ratios of cortical zones to cortex in male Wistar rats: ZG/cortex (10%), ZF/cortex (63.5%) and ZR/cortex (26.5%), which are comparable with our results.…”

Section: Discussionsupporting

confidence: 92%

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Adrenal glands of mice and rats: A comparative morphometric study

et al. 2021

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Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be related to differences in energy management, immune response, drug metabolism, behaviour and temperament. The present study tries to fill this knowledge gap with the evaluation and comparison of adrenal gland anatomical/morphometric parameters of mice and rats. In groups of 10 ( n = 10) adult, male and female BALB/c mice and Wistar rats, one in every 20 sections transverse to the longitudinal axis of the gland was used for measuring entire gland area, capsule, entire cortex, cortex zones and medulla with the aid of an image analysis system and subjected to statistical analysis. Quotients of the individual areas were calculated and comparison between the resulting ratios was performed. Gland length and volume were also calculated. Statistically significant differences were revealed between the rat female and male cortex area, rat and mouse medulla/cortex, medulla/gland, zona glomerulosa/cortex and cortex/gland ratios, male and female rats’ medulla/cortex, medulla/gland, capsule/gland, zona glomerulosa/cortex, zona reticularis/cortex and zona glomerulosa/zona fasciculata ratios, length and volume. The correlation evaluation revealed that in male rats and in female mice the larger medulla area was accompanied by a larger cortex area and vice versa. In general, a larger cortex area was accompanied by larger areas of cortex zones. The collected data and the revealed differences can possibly contribute to the understanding of the physiology of the two species.

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Section: Discussionsupporting

confidence: 92%

“…In literature, a number of studies exist about their morphometric parameters in mice [1][2][3][4] and rats. [5][6][7][8][9][10][11][12][13][14][15] To our knowledge though, there are no studies comparing morphometric parameters between the two species.…”

Section: Introductionmentioning

confidence: 99%

Adrenal glands of mice and rats: A comparative morphometric study

et al. 2021

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“…The morphology of adrenal glands is similar to that reported by various investigators (Pauly, 1957;Sabatini and DeRobertis, 1961;Rhodin, 1971;Rohr et al, 1976). The adrenal cortex of the rat consists of three morphological compartments or zones.…”

Section: Electron Microscopic Observation Of Adrenal Glands Morphologsupporting

confidence: 86%

The effect of zinc deficiency on the ultrastructure of rat adrenal cortex

1982

Am. J. Anat.

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The adrenal cortex of male Sprague-Dawley weanling rats maintained on a zinc-deficient diet was studied by electron microscopy. There was a gradual increase in lipid droplets in the zona fasciculata which was quite marked at 7 weeks, but increased lipid was not observed in the zona glomerulosa or reticularis of zinc-deficient rats. The adrenal cortex of the control animals did not show altered lipid content. A possible explanation for the effect of zinc deficiency on the adrenal cortex is offered.Address reprint requests to A.E. Leure-duPree, Ph. D.,

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“…The major aim of the present study was to obtain quantitative data on organdies thought to be important in steroid hormone production by the ovary. Steroid secreting cells from the adrenal cortex (Rohr et al, 1976), ovary (Enders, 1973 ;Long, 1973) and testis (Mori & Christensen, 1980;Zirkin, Ewing, Kromann & Cochran, 1980) have many ultrastructural characteristics in common but whether there is a common pattern in the quantitative relationship of ultrastructure to rate of hormone secretion is not known. The extensive study by Mori & Christensen (1980) has established quantitative relationships for Leydig cell ultrastructure and rate of testosterone secretion in the rat.…”

Section: Discussionmentioning

confidence: 99%

Quantitative ultrastructure of the luteal cell of the 16-day-pregnant rat and its relation to progesterone secretion

Meyer¹,

Bruce²

1984

Reproduction

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The ultrastructure of luteal cells of five Day-16 pregnant rats were examined morphometrically to determine the relationship between the quantity of steroidogenic organelles and membranes and reported rates of progesterone secretion (2.3 micrograms/h). Each rat had 11.8 +/- 1.0 corpora lutea (mean +/- s.e.m.) with an average volume of 4.5 +/- 0.1 microliter. There were 210 000 +/- 10 000 luteal cells per CL and the luteal cell cytoplasm was composed of smooth endoplasmic reticulum (18%), mitochondria (10.6%), lipid droplets (8.9%) and granules (0.6%). The surface area of the smooth endoplasmic reticulum was 192 cm2 per CL, and that of the outer and inner mitochondrial membranes was 20 and 34 cm2, respectively. For each square micrometre of these membranes, respectively, 62, 590 and 355 molecules of progesterone would have been secreted per second. The luteal cell appears to secrete its major steroid hormone at a rate 50 times greater than that reported for the Leydig cell of the testis when secretion is expressed in terms of molecules per unit mass of steroidogenic cell or area of steroidogenic membrane.

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Ultrastructural morphometric analysis of the unstimulated adrenal cortex of rats

Cited by 22 publications

References 22 publications

Adrenal glands of mice and rats: A comparative morphometric study

Adrenal glands of mice and rats: A comparative morphometric study

The effect of zinc deficiency on the ultrastructure of rat adrenal cortex

Quantitative ultrastructure of the luteal cell of the 16-day-pregnant rat and its relation to progesterone secretion

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