Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance byStreptococcus pneumoniae
Xueqing Wu,
Babek Alibayov,
Xi Xiang
et al.
Abstract:AimStreptococcus pneumoniae(Spn) acquires genes for macrolide resistance, MEGA orermB, in the human host. These genes are carried either in the chromosome, or on integrative conjugative elements (ICEs). Here, we investigated molecular determinants of the acquisition of macrolide resistance.Methods and ResultsWhole genome analysis was conducted for 128 macrolide-resistant pneumococcal isolates to identify the presence of MEGA (44.5%, 57/128) orermB(100%), and recombination events in Tn916-related elements or in… Show more
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